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MIXED-LIGAND COORDINATION POLYMERS: STRUCTURAL DIVERSITY AND PROTECTIVE EFFECT ON CARDIAC ARREST INDUCED BY ANESTHESIA VIA INDUCING Sirt1 PATHWAY

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Abstract

A reaction of the N-donor ligand 1,3-di(1H-imidazol-1-yl)benzene (dimb) with Co(NO3)2·6H2O and the V-shaped carboxylate ligand biphenyl-3,4′,5-tricarboxylic acid (H3bpt) under hydro- or solvothermal conditions yields two new Co(II)-based coordination polymers with the chemical formulas {Co3(dimb)2(bpt)2(H2O)4]}n (1) and [Co2(dimb)2(Hbpt)2]·H2O (2). Furthermore, the treatment effect of compounds 1 and 2 against cardiac arrest induced by anesthesia is evaluated. Firstly, ELISA is used to detect the content of cardiac troponin T and B brain natriuretic peptide after treatment with the compounds. Moreover, RT-PCR is conducted and the relative expression level of Sirt1 in the rat myocardial tissue is measured.

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  • 28 October 2020

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Authors and Affiliations

  1. Department of Anesthesiology, Guangrao People′s Hospital of Guangrao, Guangrao, Shandong, P.R. China

    Q. -S. Xiao

  2. Department of Anesthesiology, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, P.R. China

    G. -Z. Ren

  3. Department of Anesthesiology, Gaomi People′s Hospital of Shandong Province, Gaomi, Shandong, P.R. China

    J. -J. Li

  4. Infectious Disease Department, Qingdao Central Hospital, Qingdao University, Qingdao, Shandong, P.R. China

    H. Yin

  5. Department of Anesthesiology, Qingdao Eye Hospital of Shandong First Medical University, Shandong Eye Institute, Key Laboratory of Ophthalmology of Shandong Province-National Key Laboratory Cultivation Base Jointly Established by the Ministry of Ophthalmology, Qingdao, Shandong, P.R. China

    H. Yu

  6. Department of Anesthesiology, Bengbu Medical College, Bengbu, Anhui, P.R. China

    G. Liu

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  1. Q. -S. Xiao
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  2. G. -Z. Ren
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  3. J. -J. Li
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  4. H. Yin
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  5. H. Yu
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  6. G. Liu
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Correspondence to H. Yu.

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Xiao, Q.S., Ren, G.Z., Li, J.J. et al. MIXED-LIGAND COORDINATION POLYMERS: STRUCTURAL DIVERSITY AND PROTECTIVE EFFECT ON CARDIAC ARREST INDUCED BY ANESTHESIA VIA INDUCING Sirt1 PATHWAY. J Struct Chem 61, 1446–1453 (2020). https://doi.org/10.1134/S0022476620090127

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  • DOI: https://doi.org/10.1134/S0022476620090127

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