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TWO NEW Co(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND TREATMENT ACTIVITY ON ACUTE BACTERIAL SINUSITIS BY INHIBITING MRSA BACTERIAL GROWTH

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Abstract

Two new coordination complexes formulated as [Co(pbib)2(SO4)] (1) and [Cd(ppda)(pbib)(H2O)] (2, H2ppda = 1,4-phenylene-diacetic acid, pbib = 1,4-bis(1-imidazoly)benzene) are successfully prepared by a reaction of the pbib ligand with different metal salts and organic carboxylate ligands under the solvothermal reaction conditions. Furthermore, the treatment effect of compounds 1 and 2 on acute bacterial sinusitis (ABS) in vitro and in vivo is evaluated. Firstly, after treating with compounds 1 and 2, the bacterial growth curves of methicillin-resistant Staphylococcus aureus (MRSA) are measured. Moreover, the ELISA detection kit is applied after treatment with the compound to determine the inflammatory cytokines concentration in the blood.

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Authors and Affiliations

  1. E.N.T. Department, Cangzhou Central Hospital, Cangzhou, P.R. China

    H. Zhu, W. -N. Zuo, H. -F. Yan & P. Xu

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  1. H. Zhu
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  2. W. -N. Zuo
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  3. H. -F. Yan
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  4. P. Xu
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Correspondence to P. Xu.

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Zhu, H., Zuo, W.N., Yan, H.F. et al. TWO NEW Co(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND TREATMENT ACTIVITY ON ACUTE BACTERIAL SINUSITIS BY INHIBITING MRSA BACTERIAL GROWTH. J Struct Chem 61, 1267–1273 (2020). https://doi.org/10.1134/S0022476620080120

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  • DOI: https://doi.org/10.1134/S0022476620080120

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