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Synthesis, Crystal Structure, and Anti-Gastric Cancer Activity of a Heterometallic Coordination Polymer Based on Flexible 6,6-Dithiodinicotinic Acid

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Abstract

A new bimetallic coordination polymer [In2Na(H2O)2(ddca)3](NO3)·4H2O (1, H2ddca = 6,6′-dithiodinicotinic acid) is produced via a hydrothermal reaction of In(NO3)3, H2ddca with NaOH as the pH modulator. Various characterization methods, such as thermogravimetric analysis (TGA), elemental analysis (EA), single crystal and powder X-ray diffraction measurements, are used. Furthermore, a process of sonochemistry with oleic acid at 453 K is used to produce nanoparticles of 1 (nano-1). In terms of the biological function of the synthesized complex, the real-time reverse transcription-polymerase chain reaction is carried out to explore the relative mRNA expression of miR-181 in MGC-803, BGC-823, and SGC-7901 gastric cancer cell lines, and the western blot is used to explore the protein expression of apoptotic protein Bcl-2.

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Authors and Affiliations

  1. Gastroenterology (Internal Medicine of Abdominal Tumors), Guangfu Cancer Hospital, Jinhua, Zhejiang, P. R. China

    M. Cheng, L. -M. Fang, M. -Z. Lou & H. Jin

  2. Cardiology, Jinhua Fifth Hospital, Jinhua, Zhejiang, P. R. China

    W. Chen

  3. Paediatrics, People’s Hospital of Gansu Province, Lanzhou, Gansu, P. R. China

    B. Zhang

  4. Digestive Endoscopy Center, Laishan Branch Hospital, Yuhuangding Hospital, Yantai, Shandong, P. R. China

    L. -L. Zang

Authors
  1. M. Cheng
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  2. W. Chen
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  3. L. -M. Fang
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  4. M. -Z. Lou
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  5. H. Jin
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  6. B. Zhang
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  7. L. -L. Zang
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Correspondence to L. -L. Zang.

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Additional information

Text © The Author(s), 2020, published in Zhurnal Strukturnoi Khimii, 2020, Vol. 61, No. 6, pp. 1040–1046.

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Cheng, M., Chen, W., Fang, L.M. et al. Synthesis, Crystal Structure, and Anti-Gastric Cancer Activity of a Heterometallic Coordination Polymer Based on Flexible 6,6-Dithiodinicotinic Acid. J Struct Chem 61, 987–993 (2020). https://doi.org/10.1134/S0022476620060207

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  • DOI: https://doi.org/10.1134/S0022476620060207

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