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A New Ni(II)-Containing Coordination Complex Based on Carboxylate and Multinitrogen Co-Ligands: Crystal Structure and Protective Effect on Type 2 Diabetes by Down-Regulating PKC and MAPK Activation

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Abstract

In this study, a new Ni(II)-containing coordination complex [Ni2(H2O)2(Li)(L2)2] (1) is successfully prepared by the reaction of Ni(NO3)2·6H2O, 5,5′-((1,4-phenylenebis(methylene))bis-(azanediyl))diisophthalic acid (H4L1), and 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2′-bipyridine (L2) in a mixed solvent of DMF and water. Various characterization methods such as the elemental analysis and single crystal X-ray diffraction are used to probe the structural composition and the agreement of the as-prepared metal-coordination complex. Furthermore, nanosized complex 1 is prepared via the refluxing method, and the transmission electron microscopy images confirm the nanosize of the particles and their homogeneous distribution. To evaluate the treatment activity of nano-1 on the type 2 diabetes, the HepG2 liver cells are treated with the compound. The relative expression of PKC and MAPK in gene and the protein level are detected by RT-PCR and Western blot, respectively.

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Authors and Affiliations

  1. Department of Endocrinology, Wuwei People’s Hospital, Wuwei, Gansu, P. R. China

    H. Tai

  2. Department of Otolaryngology, Wuwei People’s Hospital, Wuwei, Gansu, P. R. China

    S. Wang

  3. Hubei University of Chinese Medicine, Wuhan, Hubei, P. R. China

    X. Wang

  4. Integrated TCM and Western Medicine, Hubei Cancer Hospital, Wuhan, Hubei, P. R. China

    X. Wang

  5. Department of Health Economics, School of Health Management, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China

    X. Gong

  6. Sun Simiao Hospital, Beijing University of Chinese Medicine, Beijing, P. R. China

    Y. Guo

Authors
  1. H. Tai
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  2. S. Wang
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  3. X. Wang
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  4. X. Gong
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  5. Y. Guo
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Corresponding author

Correspondence to Y. Guo.

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The authors declare that they have no conflict of interests.

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Text © The Author(s), 2020, published in Zhurnal Strukturnoi Khimii, 2020, Vol. 61, No. 6, pp. 1008–1015.

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Tai, H., Wang, S., Wang, X. et al. A New Ni(II)-Containing Coordination Complex Based on Carboxylate and Multinitrogen Co-Ligands: Crystal Structure and Protective Effect on Type 2 Diabetes by Down-Regulating PKC and MAPK Activation. J Struct Chem 61, 955–962 (2020). https://doi.org/10.1134/S0022476620060165

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  • DOI: https://doi.org/10.1134/S0022476620060165

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