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Crystal Structure of Three Ionic Compounds of Levofloxacin

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Abstract

The structures of three ionic compounds of levofloxacin (LevoH or Ci18H20FN3O4) − LevoH3[CoCl4]-H2O (I), LevoH3[ZnBr4]·H2O (II), LevoH3[CuBr4]-H2O·(III) are determined. The crystals of I-III are monoclinic; in compound III, the particles are packed so that the direction of the screw axis does not coincide with the largest unit cell parameter. The asymmetric unit of the unit cell contains two LevoH32+ and CoCl42− ions and two crystallization water molecules in I; two LevoH32+ and MBr42− (M = Cu, Zn) ions and two crystallization water molecules in II and III. The absolute structure of the crystals and the configuration of the chiral center of the levofloxacinium cation S are determined. The structures are stabilized by multiple hydrogen bonds, X−Y π and π-π interactions.

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Funding

The work was performed within the State Task of the Ministry of Education and Science of the Russian Federation to the Siberian Federal University for 2017-2019 (4.7666.2017/BCh).

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Authors and Affiliations

  1. Siberian Federal University, Krasnoyarsk, Russia

    A. D. Vasiliev & N. N. Golovnev

  2. Kirensky Institute of Physics, Federal Research Center, Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russia

    A. D. Vasiliev

Authors
  1. A. D. Vasiliev
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  2. N. N. Golovnev
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Correspondence to N. N. Golovnev.

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Conflict of Interests

The authors declare that they have no conflict of interests.

Russian Text © The Author(s), 2019, published in Zhurnal Strukturnoi Khimii, 2019, Vol. 60, No. 12, pp. 2044-2049.

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Vasiliev, A.D., Golovnev, N.N. Crystal Structure of Three Ionic Compounds of Levofloxacin. J Struct Chem 60, 1959–1964 (2019). https://doi.org/10.1134/S0022476619120114

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  • DOI: https://doi.org/10.1134/S0022476619120114

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