Abstract
The complexes of 4-(2,4,6-trichlorophenyl)-3-thiosemicarbazide (HL1) with transition metal cations VO(II), Co(II), Ni(II), Cu(II), Pd(II), and Pt(II) are prepared and characterized using elemental and thermal analyses, UV-visible spectrophotometry, FTIR, mass, and NMR spectroscopy, X-ray diffraction, and molar conductance and magnetic susceptibility measurements. The results show that the prepared chelates have the following chemical formulae and structures: [(VO)2(L1)(SO4)(C2H5O)·H2O] (square based pyramidal structure), [Co2(HL1)Cl3C2H5OH]·Cl (square planar structure), [Ni(HL1)Cl2]·3H2O (square planar structure), [Cu(L1)2(H2O)2] (octahedral structure), [Pd(HL1)Cl2]·H2O (weakly distorted square planar structure), and [Pt(HL1)Cl2]·1/2H2O (square planar structure). Generally, the complexes exhibit a high thermal stability, however, the Pd(II) and Pt(II) complexes are more stable than the other complexes. The ligand (HL1), and its complexes are screened for their biological activity. Some of the complexes are found more biologically active than the parent ligand.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
S. Shariar, M. Jesmin, and M. Ali. Int. Lett. Chem., Phys. Astron., 2014, 7, 53–61.
M. Devereux, D. O. Shea, A. Kellett, M. McCann, M. Walsh, D. Egan, C. Deegan, K. Kędziora, G. Rosair, and H. Müller-Bunz. J. Inorg. Biochem., 2007, 101, 881–892.
T. A. Yousef, G. M. Abu El-Reash, O. A. El-Gammal, and R. A. Bedier. J. Mol. Struct., 2012, 1029, 149–160.
P. Tarasconi, S. Capacchi, G. Pelosi, M. Cornia, R. Albertini, A. Bonati, P. P. Dall’Aglio, P. Lunghi, and S. Pinelli. Bioorg. Med. Chem., 2000, 8, 157–162.
D. Nasrin, M. Ashraful Alam, M. N. Hossain, and M. Nazimuddin. Chem. J., 2013, 3, 13–19.
E. Pahontu, F. Julea, T. Rosu, V. Purcarea, Y. Chumakov, P. Petrenco, and A. Gulea. J. Cell. Mol. Med., 2015, 19, 865–878.
S. Pandeya, D. Sriram, G. Nath, and E. DeClercq. Eur. J. Pharm. Sci., 1999, 9, 25–31.
S. Prasad and R. Agarwal. Trans. Metal Chem., 2007, 33, 143–149.
N. Murthy and T. S. Dharmarajan. Asian J. Chem., 2006, 14, 1325–1330.
S. Sevagapandian, G. Rajagopal, K. Nehru, and P. Athappan. Trans. Metal Chem., 2000, 25, 388–393.
R. C. Maurya, B. A. Malik, J. M. Mir, P. K. Vishwakarma, D. K. Rajak, and N. Jain. J. Coord. Chem., 2015, 68, 2902–2922.
B. Paterson and P. Donnelly. Chem. Soc. Rev., 2011, 40, 3005–3018.
R. Hueting, V. Kersemans, M. Tredwell, B. Cornelissen, M. Christlieb, A. D. Gee, J. Passchier, S.C. Smart, V. Gouverneur, R. J. Muschel, and J. R. Dilworth. Metallomics, 2015, 7, 795–804.
W. Liu, X. Li, Z. Li, M. Zhang, and M. Song. Inorg. Chem. Comm., 2007, 10, 1485–1488.
T. A. Yousef, G. M. Abu El-Reash, O. A. El-Gammal, and R. A. Bedier. J. Mol. Struct., 2012, 1029, 149–160.
S. M. Ying. Inorg. Chem. Comm., 2012, 22, 82–84.
N. El-Metwally, R. El-Shazly, I. Gabr, and A. El-Asmy. Spectrochim. Acta A, 2005, 61, 1113–1119.
B. Jeragh and A. El-Asmy. Spectrochim. Acta A, 2014, 130, 546–552.
S. Chandra and M. Tyagi. Int. Chem. Sci., 2009, 7, 116–124.
Acknowledgments
The support of the University of Kuwait through the College of Graduate Studies (M.Sc. thesis of Ms. Manal Marzouk) is gratefully acknowledged.
Funding
This work was supported by the Research Sector Projects Unit (RSPU) (Grant numbers: GS01/01, GS01/05, GS02/01, GS03/01, and GS03/08).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The authors declare that they have no conflict of interests.
Additional information
Text © The Author(s), 2019, published in Zhurnal Strukturnoi Khimii, 2019, Vol. 60, No. 11, pp. 1892–1900.
Rights and permissions
About this article
Cite this article
Shoukry, A., Al-Fulaij, O., Marzouk, M. et al. Structure and Biological Activity of Trichlorophenyl-Thiosemicarbazone and its Complexes with Some Transition Metal Cations. J Struct Chem 60, 1818–1826 (2019). https://doi.org/10.1134/S0022476619110167
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0022476619110167