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Synthesis, Crystal Structure, DNA Binding, and Cytotoxicity of a Zn(II) Complex Constructed from Phenylacetic Acid

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Abstract

A novel Zn(II) complex with the formula {[ZnL2(dibe)2]·2H2O}n (synthesized using a carboxylic acid ligand, L = phenylacetic acid, dibe = 4,4′-bipyridine (bipy)) is synthesized at room temperature, characterized and its DNA binding, cleavage, anticancer properties are studied by elemental analysis, infrared spectroscopy, and single crystal X-ray diffraction. The interaction of the complex with fish sperm DNA (FS-DNA) is monitored, which reveals that the complex has the ability to bind to FS-DNA. The complex is further studied for the gel electrophoresis assay with supercoiled plasmid pBR322 DNA. In addition, anticancer activities of the metal complex investigated through MTT in vitro assays, indicate that the complex shows good cytotoxic activity against cancer cell lines. Flow cytometry and apoptosis experiments show that the complex induces apoptosis of HeLa cells, which demonstrates that the complex exhibits a significant cancer cell inhibitory rate.

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Funding

We gratefully acknowledge the Natural Science Foundation of China (No. 21171118) and the Distinguished Professor Project of Liaoning province.

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Authors and Affiliations

  1. Shenyang Institute of Science and Technology, Shenyang, P. R. China

    X. N. Gao

  2. Department of Coordination Chemistry, International Key Laboratory of Shenyang, Inorganic Molecule-Based Chemical, Shenyang University of Chemical Technology, Shenyang, P. R. China

    E. J. Gao & M. C. Zhu

Authors
  1. X. N. Gao
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  2. E. J. Gao
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  3. M. C. Zhu
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Corresponding authors

Correspondence to X. N. Gao or E. J. Gao.

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Text © The Author(s), 2019, published in Zhurnal Strukturnoi Khimii, 2019, Vol. 60, No. 7, pp. 1226-1234.

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Gao, X.N., Gao, E.J. & Zhu, M.C. Synthesis, Crystal Structure, DNA Binding, and Cytotoxicity of a Zn(II) Complex Constructed from Phenylacetic Acid. J Struct Chem 60, 1180–1188 (2019). https://doi.org/10.1134/S0022476619070217

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  • DOI: https://doi.org/10.1134/S0022476619070217

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