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Effect of caffeine on DNA conformational changes after in vitro γ-irradiation

  • Proceedings of the 15th Symposium on Intermolecular Interactions and Conformations of Molecules Petrozavodsk, 2010, June 14–18
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Abstract

The radioprotective action of caffeine upon γ irradiation of DNA solutions is demonstrated by means of low gradient viscometry, flow birefringence, atomic force microscopy and UV spectroscopy. In the presence of caffeine, a decrease in the radiation effect on the DNA coil size in the solution, in the number of doublestranded breaks and damaged nitrogen bases, and in the degree of radiation-induced denaturation is observed.

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Authors and Affiliations

  1. Physics Department, St. Petersburg State University, St. Petersburg, Russia

    S. V. Paston & A. E. Tarasov

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  1. S. V. Paston
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  2. A. E. Tarasov
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Correspondence to S. V. Paston.

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Original Russian Text Copyright © 2011 by S. V. Paston and A. E. Tarasov

__________

Translated from Zhurnal Strukturnoi Khimii, Vol. 52, No. 6, pp. 1246–1251, November–December, 2011.

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Paston, S.V., Tarasov, A.E. Effect of caffeine on DNA conformational changes after in vitro γ-irradiation. J Struct Chem 52, 1209–1214 (2011). https://doi.org/10.1134/S0022476611060291

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  • DOI: https://doi.org/10.1134/S0022476611060291

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