Abstract
Chemical modification of polyethylene glycols by antioxidants belonging to the class of sterically hindered phenols is used to obtain water-soluble conjugates differing in the structure of the joined antioxidant and molecular weight. The inclusion of hydrophobic end groups in polyethylene glycol molecules leads to a decrease in the lower critical mixing point of the solution as compared to the original polymer. Dilute solution viscometry and light scattering are used to determine the molecular-mass characteristics of the polymers and the hydrodynamic radii of single conjugate molecules. The mass fraction of single molecules in aqueous solutions of the conjugates is greater than 95%. The aggregates are micellar-type particles whose core is formed by the hydrophobic moieties of sterically hindered phenols. It is shown that the antiradical activity of the antioxidants 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)-propionic acid and 3- (3,5-di-tert-butyl-4-hydroxyphenyl)-propionic acid, which are used for the modification, differs only slightly, whereas the activity of the relevant conjugates increases significantly.
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Original Russian Text Copyright © 2011 by L. A. Dobrun, E. L. Kuzyakina, O. V. Rakitina, O. Yu. Sergeeva, M. E. Mikhailova, N. S. Domnina, and A. V. Lezov
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Translated from Zhurnal Strukturnoi Khimii, Vol. 52, No. 6, pp. 1197–1202, November–December, 2011.
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Dobrun, L.A., Kuzyakina, E.L., Rakitina, O.V. et al. Molecular characteristics and antioxidant activity of polyethylene glycols modified by sterically hindered phenols. J Struct Chem 52, 1161–1166 (2011). https://doi.org/10.1134/S0022476611060229
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DOI: https://doi.org/10.1134/S0022476611060229