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Methods for Assessing Left Ventricular Diastolic Distensibility

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Abstract

The major property of the myocardium that determines left ventricular (LV) filling is its distensibility. The simplest measure for its assessment is the LV end-diastolic pressure–volume ratio, although it can vary within a wide range and is highly dependent on inflow and resistance boundary conditions, making distensibility difficult to assess. Here, we consider six calculated indices of LV diastolic stiffness, most of which are based on Hooke’s law, comparing their stability, variation, and correlation coefficients with different hemodynamic parameters. The diastolic stiffness index No. 4 proved to be the only measure that takes into account an increase in LV stiffness over diastole. It shows a weak dependence on LV ejection fraction, heart rate, and other parameters of LV hemodynamics, and hence can be used to assess LV diastolic distensibility in various cardiac pathologies.

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Funding

This work was supported by the Russian Science Foundation (project No. 23-15-00275). No additional grants were obtained to carry out or supervise this particular research.

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Authors and Affiliations

  1. Chazov National Medical Research Center of Cardiology, Moscow, Russia

    V. I. Kapelko, V. L. Lakomkin, A. A. Abramov & A. V. Prosvirnin

Authors
  1. V. I. Kapelko
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  2. V. L. Lakomkin
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  3. A. A. Abramov
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  4. A. V. Prosvirnin
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Contributions

V.I.K. and V.L.L.—conceptualization and experimental design; A.A.A., A.V.P., V.L.L.—data collection; A.A.A., A.V.P., V.L.L., V.I.K.—data processing and representation; V.L.L., V.I.K., A.A.A.—writing and editing the manuscript.

Corresponding author

Correspondence to V. L. Lakomkin.

Ethics declarations

ETHICS APPROVAL

Experiments with animals were conducted in compliance with the NIH Guidelines for the care and use of laboratory animals (http://oacu.od.nih.gov/regs/index.htm) and were approved by the Bioethics Committee at Chazov National Medical Research Center for Cardiology (Minutes No. LEPS/18.07.2023).

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

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Translated by A. Polyanovsky

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Kapelko, V.I., Lakomkin, V.L., Abramov, A.A. et al. Methods for Assessing Left Ventricular Diastolic Distensibility. J Evol Biochem Phys 60, 391–396 (2024). https://doi.org/10.1134/S0022093024010290

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  • DOI: https://doi.org/10.1134/S0022093024010290

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