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Exploratory and Locomotor Activity in Mice Following Selective Lesions of the Hippocampus: Effects of Lesion Site and Open Field Arena Size

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Abstract

The present study showed arena size-dependent effects on the impairment of locomotor activity and rearing after lesions of caudal hippocampus in C57BL/6 mice: intensive high-speed locomotion without intra- and intertrial habituation accompanied by a decreased number of rears and a reduced tortuosity of the route, suggesting significant impairments of exploratory behavior in an unfamiliar large environment. The lesions of the rostral hippocampus resulted in slight hyperactivity in the large arena without impairment of habituation or rearing. The caudal hippocampus is thus crucial for the environment-dependent modifications of exploratory behavior. Changes on exploratory behavior after its lesions are similar to ones following more extensive or complete lesions of the hippocampus.

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ACKNOWLEDGMENTS

The authors are grateful to I.V. Lebedev for his help in carrying out experiments.

Funding

Supported by RFBR 20-015-00287.

The research was carried out within the project of state assignment of MSU No. 121032500080-8.

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Authors and Affiliations

  1. Department of Biology, Lomonosov Moscow State University, Moscow, Russia

    P. A. Kuptsov & M. G. Pleskacheva

  2. Department of Experimental Psychology, University of Oxford, Oxford, UK

    R. M. J. Deacon

  3. Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, Russia

    K. V. Anokhin

  4. P.K. Anokhin Research Institute of Normal Physiology, Moscow, Russia

    K. V. Anokhin

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  1. P. A. Kuptsov
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  2. R. M. J. Deacon
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  3. K. V. Anokhin
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  4. M. G. Pleskacheva
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Contributions

Conceptualization: Pleskacheva MG, Anokhin KV; Methodology: Deacon RMG, Kuptsov PA; Formal analysis and investigation: Kuptsov PA, Pleskacheva MG; Writing: original draft preparation: Pleskacheva MG, Kuptsov PA; Writing: review and editing: Pleskacheva MG, Deacon RMG, Anokhin KV.

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Correspondence to M. G. Pleskacheva.

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The online version contains supplementary material available at 10.1134/S0022093023040099.

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Kuptsov, P.A., Deacon, R.M.J., Anokhin, K.V. et al. Exploratory and Locomotor Activity in Mice Following Selective Lesions of the Hippocampus: Effects of Lesion Site and Open Field Arena Size. J Evol Biochem Phys 59, 1112–1135 (2023). https://doi.org/10.1134/S0022093023040099

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