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Heart Electrical Activity during Ventricular Repolarization in Rats after Acute Exhaustive Treadmill Running

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Abstract

The article is focused on the evaluation of the electrical activity of the heart in rats during ventricular repolarization after a single bout of forced treadmill running until exhaustion. Electrophysiological properties of the myocardium were studied by conventional ECG and body surface potential mapping. Cardiac potentials were registered in zoletil-anesthetized rats 3–5 days before (baseline) and 5, 10, 20 and 30 min after exhaustive treadmill running. Compared with baseline, an increase in the duration of the QTII, JTII and Tpeak–TendII intervals, an earlier onset and a later completion, as well as an increase in the duration of ventricular repolarization on body surface equipotential maps (BSPMs) were revealed in rats 5 min after exhaustive exercise. Ten min following treadmill running to exhaustion, the temporal parameters of the heart electrical activity returned to pre-exercise values. Changes in the amplitude characteristics of both ECGII (ST segment depression, a decrease in the T-wave amplitude) and BSPMs (a decrease in the maximum amplitudes of positive and negative extrema during ventricular repolarization) were showed after 5–10 min and persisted up to 20–30 min after running to exhaustion. A positive correlation was found between changes in the maximum amplitude of negative extremum of BSPMs and changes in the amplitude of the TII-wave in the analyzed time periods after exhausting exercise. It is assumed that the observed changes in the electrical properties of the heart in rats during ventricular repolarization after forced treadmill running were due to ischemic myocardial damage induced by exhaustive physical exercise.

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Funding

The research was performed in the framework of the state assignment AAA-A18-118012390260-9.

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Authors and Affiliations

  1. Federal Research Center Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia

    A. G. Ivonin & S. L. Smirnova

  2. Zakusov Institute of Pharmacology, Moscow, Russia

    I. M. Roshchevskaya

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  1. A. G. Ivonin
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  2. S. L. Smirnova
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  3. I. M. Roshchevskaya
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Contributions

Idea of work and planning the experiment (A.G.I., S.L.S., I.M.R.), data collection (A.G.I., S.L.S., I.M.R.) data processing, writing the article (A.G.I.), editing the article (I.M.R.).

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Correspondence to A. G. Ivonin.

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The authors declare no apparent or potential conflicts of interest related to the publication of this article.

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Translated by A. Dyomina

Russian Text © The Author(s), 2022, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2022, Vol. 108, No. 10, pp. 1340–1352https://doi.org/10.31857/S0869813922100089.

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Ivonin, A.G., Smirnova, S.L. & Roshchevskaya, I.M. Heart Electrical Activity during Ventricular Repolarization in Rats after Acute Exhaustive Treadmill Running. J Evol Biochem Phys 58, 1632–1642 (2022). https://doi.org/10.1134/S0022093022050313

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