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fMRI Studies of Opponent Interregional Interactions in the Macaca mulatta Brain

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Abstract

In neurophysiological studies, functional magnetic resonance imaging (fMRI) is most commonly used to map brain functions by locating areas of increased activity while executing various tests. At the same time, less attention is traditionally paid to a concomitant decrease in metabolism in other brain areas despite a comparable intensity of these processes. The cause for such a decrease in local brain activity, as well as its dynamics and the dependence of localization on experimental conditions, are currently in question. The aim of this work was to study the interaction between brain regions that demonstrate bidirectional changes in the level of oxygen consumption in response to the simplest stimuli, flashes of light. The study was carried out on three awake Macaca mulatta monkeys, in which activity distribution maps were compared during aperiodic light stimulation and in total darkness. Flashes of light evoked an increase in oxygen consumption in the primary visual cortex and a simultaneous decrease in this indicator in field 7 of the parietal cortex and in area V5 of the middle temporal area. Brain areas that decreased their activity usually did not respond to flickering light stimulation and were not involved in signal processing under conditions of our experiments. The data obtained are interpreted in the light of the hypothesis of an automatic maintenance of a balance between activated and deactivated brain areas, aimed at saving brain energy resources. Presumably, a decrease in activity relative to the background level in unused areas would help compensate for increased energy consumption in other brain areas responsible for signal processing.

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ACKNOWLEDGMENT

The authors are grateful to I.A. Varovina for technical assistance throughout the project.

Funding

This study was state budget funded, supported by the State Program 47 GP “Scientific and Technological Development of the Russian Federation” (2019–2030), theme no. 0134-2019-0006.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. K. Harauzov, L. E. Ivanova, P. P. Vasiliev & D. N. Podvigina

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  1. A. K. Harauzov
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  2. L. E. Ivanova
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  3. P. P. Vasiliev
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  4. D. N. Podvigina
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Contributions

Experimental design—A.K.H.; data collection—A.K.H., L.E.I., P.P.V., data processing—A.K.H., P.P.V., D.N.P.; writing a manuscript—A.K.H.; editing a manuscript—D.N.P.

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Correspondence to A. K. Harauzov.

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CONFLICT OF INTEREST

The authors declare that they have neither evident nor potential conflict of interest associated with the publication of this article.

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Translated by A. Polyanovsky

Russian Text © The Author(s), 2022, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2022, Vol. 58, No. 4, pp. 311–322https://doi.org/10.31857/S0044452922040064.

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Harauzov, A.K., Ivanova, L.E., Vasiliev, P.P. et al. fMRI Studies of Opponent Interregional Interactions in the Macaca mulatta Brain. J Evol Biochem Phys 58, 1001–1014 (2022). https://doi.org/10.1134/S0022093022040068

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