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Does Atrial Electrical Stimulation Influence the Sequence of Ventricular Depolarization in the Heart of a Rainbow Trout Oncorhynchus mykiss?

  • Comparative and Ontogenic Physiology
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Abstract

Depolarization of the heart ventricles at an increasing heart rate was investigated in a rainbow trout Oncorhynchus mykiss (n = 14). It was shown that at an imposed supraventricular rhythm ranging from 30 to 60 bpm the depolarization wave initially propagates from the loci of earliest atrial excitation located near the atrioventricular orifice to the subendocardial trabecular layer of the noncompact myocardium and then travels towards the epicardium as well as along the wall. This indicates some preferential pathways of cardiac excitation conduction from the pacemaker zone to subendocardial myocytes. Regardless of the heart rate, the basic pattern of ventricular excitation in the rainbow trout heart consists in the propagation of the depolarization wave, which captures the entire thickness of the myocardial wall and activates the subendocardium faster than the subepicardium, from the dorsal regions of the cardiac base in basoapical and ventral directions. At a rhythm of 50–60 bpm, propagation of the depolarization wave in the basal ventricular areas is inverted from the dorsoventral to ventrodorsal direction.

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Funding

This work was implemented within the theme “A comparative physiological investigation of the spatiotemporal organization of electrophysiological processes and myocardial contractility in vertebrates” (reg. no. АААА-А17-117012310154-6) under the Program of Fundamental Scientific Studies for 2013–2021.

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Authors and Affiliations

  1. Institute of Physiology, Komi Science Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia

    N. A. Kibler, V. P. Nuzhny, S. N. Kharin & D. N. Shmakov

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  1. N. A. Kibler
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  2. V. P. Nuzhny
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  3. S. N. Kharin
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  4. D. N. Shmakov
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Correspondence to N. A. Kibler.

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All applicable international, national and insttutional principles of handling and using experimental animals for scientific purposes were observed. This study did not involve human subjects as research objects.

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Russian Text © The Author(s), 2020, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2020, Vol. 56, No. 1, pp. 42–47.

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Kibler, N.A., Nuzhny, V.P., Kharin, S.N. et al. Does Atrial Electrical Stimulation Influence the Sequence of Ventricular Depolarization in the Heart of a Rainbow Trout Oncorhynchus mykiss?. J Evol Biochem Phys 56, 41–46 (2020). https://doi.org/10.1134/S0022093020010056

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  • DOI: https://doi.org/10.1134/S0022093020010056

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