Effect of Early Sucrose Diet on Ethanol Preference and Behavior in Male and Female Wistar Rats

  • M. V. DorofeikovaEmail author
  • E. V. Filatova
  • A. A. Orlov
  • A. Yu. Egorov
Comparative and Ontogenic Physiology


The effect of adolescent sucrose diet on ethanol preference was studied in female and male Wistar rats. Our data show less pronounced ethanol preference in females. In males, pubertal exposure to sucrose was crucial for further ethanol preference, suggesting that cross-sensitization is more inherent to males than females, for whom the increased anxiety factor proved to be more significant. Finally, it was shown that in rats of both sexes habitual alcohol intake determins ethanol preference in the two-bottle test. Overall, our study demonstrates sex differences in ethanol preference as well as its anxiolytic properties.

Key words

ethanol anxiety sex differences rats two-bottle test open field 


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • M. V. Dorofeikova
    • 1
    • 2
    Email author
  • E. V. Filatova
    • 1
  • A. A. Orlov
    • 1
  • A. Yu. Egorov
    • 1
    • 3
    • 4
  1. 1.Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Academy of SciencesSt. PetersburgRussia
  2. 2.St. Petersburg Bekhterev Psychoneurological Research InstituteSt. PetersburgRussia
  3. 3.St. Petersburg State UniversitySt. PetersburgRussia
  4. 4.North-Western State Medical University named after I. I. MechnikovSt. PetersburgRussia

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