Skip to main content
SpringerLink
Log in

The Effect of Intranasal Administration of Proinsulin C-peptide and Its C-terminal Fragment on Metabolic Parameters in Rats with Streptozotocin Diabetes

  • Short Communications
  • Published:
Journal of Evolutionary Biochemistry and Physiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Landreh, M., Johansson, J., and Jörnvall, H., Cpeptide: a molecule balancing insulin states in secretion and diabetes-associated depository conditions, Horm. Metab. Res., 2013, vol. 45, no. 11, pp. 769–773.

    Article  PubMed  CAS  Google Scholar 

  2. Yosten, G.L., Kolar, G.R., Redlinger, L.J., and Samson, W.K., Evidence for an interaction between proinsulin C-peptide and GPR146, J. Endocrinol., 2013, vol. 218, no. 2, pp. B1–B8.

    Article  CAS  PubMed  Google Scholar 

  3. Hach, T., Forst, T., Kunt, T., Ekberg, K., Pfützner, A., and Wahren, J., C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients, Exp. Diabetes Res., 2008, vol. 2008. ID 730594. doi: 10.1155/2008/730594

  4. Wahren, J., Kallas, A., and Sima, A.A., The clinical potential of C-peptide replacement in type 1 diabetes, Diabetes, 2012, vol. 61, no. 4, pp. 761–772.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Sato, Y., Oshida, Y., Han, Y.Q., Morishita, Y., Li, L., Ekberg, K., Jörnvall, H., and Wahren, J., C-peptide fragments stimulate glucose utilization in diabetic rats, Cell. Mol. Life Sci., 2004, vol. 61, no. 6, pp. 727–732.

    Article  PubMed  CAS  Google Scholar 

  6. Derkach, K.V., Bogush, I.V., Berstein, L.M., and Shpakov, A.O., The influence of intranasal insulin on hypothalamic-pituitary-thyroid axis in normal and diabetic rats, Horm. Metab. Res., 2015, vol. 47, no. 2, pp. 916–924.

    PubMed  CAS  Google Scholar 

  7. Pinger, C.W., Entwistle, K.E., Bell, T.M., Liu, Y., and Spence, D.M., C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?, Mol. Biosyst., 2017, vol. 13, no. 8, pp. 1432–1437.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    K. V. Derkach, V. M. Bondareva & A. O. Shpakov

  2. St. Petersburg State University, St. Petersburg, Russia

    E. A. Shpakova & A. O. Shpakov

Authors
  1. K. V. Derkach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Shpakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. M. Bondareva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. O. Shpakov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. O. Shpakov.

Additional information

Original Russian Text © K.V. Derkach, E.A. Shpakova, V.M. Bondareva, A.O. Shpakov, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 3, pp. 212–214.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Derkach, K.V., Shpakova, E.A., Bondareva, V.M. et al. The Effect of Intranasal Administration of Proinsulin C-peptide and Its C-terminal Fragment on Metabolic Parameters in Rats with Streptozotocin Diabetes. J Evol Biochem Phys 54, 242–245 (2018). https://doi.org/10.1134/S0022093018030092

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0022093018030092

Search

Navigation