Abstract
The profile of saturated fatty acid (SFA) and their relationship with the parameters of carbohydrate metabolism were investigated in 12–16-year-old adolescents from the sub-Arctic and Arctic regions of the European and Asian North of Russia. SFA levels were measured by gas-liquid chromatography; carbohydrate parameters (glucose–Glu, lactate–Lac, pyruvate–Pyr levels) were assayed by spectrophotometry; the Lac/Pyr ratio and total levels of medium-chain (ΣMC) and long-chain (ΣLC) SFA were calculated. Data were statistically processed using descriptive and correlation analyses. The multidirectional dynamics of MC SFA was established: lauric and myristic acid levels were decreased while undecanoic and pentadecanoic acid levels were increased in adolescents of the Arctic vs. sub-Arctic regions. The ΣLC SFA level was increased due to virtually all LC SFA against the background of decreased Glu Lac and Lac/Pyr values as well as slightly increased Pyr level. At the same time, in the Arctic region correlative relationships between SFA and Glu levels were negative, between SFA and Lac and Lac/Pyr–positive, whereas in the sub-Arctic region the signs of relationships were opposite.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Perova, N.V., Metelskaya, V.A., Sokolov, E.I., Shchukina, G.N., and Fomina, V.M., Alimentary fatty acids. The influence on the risk of cardiovascular diseases, Rats. Farmakoter. Kardiol., 2011, vol. 7, no. 5, pp. 620–627.
Simonova, G.I., Tutelyan, V.A., and Pogozheva, A.V., Nutrition and atherosclerosis, Byul. SO RAMN, 2006, no. 2, pp. 80–85.
Siri-Tarino, P.W., Sun, Q., Hu, F.B., and Krauss, R.M., Saturated fat, carbohydrate and cardiovascular disease, Am. J. Clin. Nutr., 2010, vol. 91, pp. 502–509.
Panin, L.E., Homeostasis and problems of sub-Arctic medicine (methodological aspects of adaptation), Byul. SO RAMN, 2010, no. 3, pp. 6–11.
Pirogov, A.B., Neuroendocrine organization of adaptation of residents of the North-East of Russia, Byul. Fiziol. Patofiziol. Dykh., 1998, no. 1, pp. 14–27.
Bychkaev, A.A., Bychkaeva, F.A., Volkova, N.I., Denisovskaya, V.Yu., Shengof, B.A., and Galstyan, D.S., The blood level of carbohydrate metabolites and long-chain saturated fatty acids in residents of the Arctic and sub-Arctic territories, Prirodnye resursy i kompleksnoe osvoenie pribrezhnykh raionov Arkticheskoi zony (Natural Resources and Integrated Development of Arctic Coastal Regions), Proc. 2nd Int. Sci. Conf., Pavlenko, V.I., Ed., Arkhangelsk, 2016, pp. 40–45.
Vlasova, O.S., Carbohydrate metabolism in children and adolescents of the North, Voprosy sokhraneniya i razvitiya zdorovya naseleniya Severa i Sibiri (Issues of Health Preservation and Development in the Population of the North and Siberia), Proc. Sci.-Pract. Conf., iss. 11, Manchuk, V.T. and Smirnova, S.V., Eds., Krasnoyarsk, 2012, pp. 45–46.
Vlasova, O.S., Bychkaeva, F.A., Volkova, N.I., and Tretyakova, T.V., Correlations between indicators of carbohydrate metabolism and supply of bioelements, vitamins B1 and B2 in childrens’ and adolescent population of the North, Ekol. Chel., 2016, no. 6, pp. 15–20.
Boiko, E.R., Fiziologo-biokhimicheskie osnovy zhiznedeyatel’nosti cheloveka na Severe (Physiological and Biochemical Basis of Human Vital Activity in the North), Ekaterinburg, 2005.
Dogadin, S.A., Nozdrachev, K.G., Krizhanovskaya, E.V., and Manchuk, V.T., Insulin, C-peptide and cortisol levels in the dynamics of the glucose tolerance test in indigenous and alien people of the Extreme North, Probl. Endokrin., 1997, vol. 43, no. 2, pp. 7–10.
Ammosova, A.M., Khandy, M.V., Zakharova, N.M., Markova, S.V., Miller, O.P., and Savina, I.L., Nutrition of children, adolescents and students of the Republic of Sakha (Yakutia) as assessed by a single-time questionnaire, Yakut. Med. Zh., 2015, no. 3, pp. 27–30.
Zilov, V.G. and Smirnov, V.M., Fiziologiya detei i podrostkov: uchebnoe posobie (Physiology of Children and Adolescents), Moscow, 2008.
Bezrukikh, M.M., Sonkin, V.D., and Farber, D.A., Vozrastnaya fiziologiya (Fiziologiya razvitiya rebenka) [Age Physiology (Physiology of Child’s Development)], 2nd ed., Moscow, 2007.
Pyatnitskaya, I.N., Chernobrovkina, T.V., and Nai denova, N.G., Klinicheskie i fermentativnye me to dy diagnostiki alkogolizma: metodicheskie rekomendatsii MZ RSFSR (Clinical and Enzymatic Methods of Acoholism Diagnostics: Methodical Recommendations of the Ministry of Health of the RSFSR), Moscow, 1984.
Folch, J., Less, M., and Stanley, G.H.S., A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem., 1957, vol. 226, pp. 497–509.
Mansurova, I.D. and Sultanova, U.K., Determination of the higher fatty acid level in blood serum of healthy and chronic pancreatitis patients by gas chromatography, Lab. Delo, 1985, no. 9, pp. 524–527.
Yunkerov, V.I. and Grigoryev, S.G., Matematikostatisticheskaya obrabotka dannykh meditsinskikh issledovanii (Mathematical and Statistical Analysis of Medical Data), St. Petersburg, 2002.
Kendysh, I.N., Regulyatsiya uglevodnogo obmena (Regulation of Carbohydrate Metabolism), Moscow, 1985.
Titov, V.N., Insulin resistance as a blockade of receptor-mediated uptake of saturated fatty acids by myocytes in the form of triglycerides, Klin. Lab. Diagnost., 2003, no. 11, pp. 3–10.
Velkov, V.V., Free fatty acids, a novel marker of insulin resistance and ischemia, Klin.-Lab. Konsil., 2008, no. 5, pp. 4–16.
Titov, V.N., Medium-chain FA: food levels, physiology, metabolic peculiarities, and clinical use, Vopr. Pit., 2012, vol. 81, no. 6, pp. 27–36.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © O.S. Vlasova, F.A. Bichkaeva, T.V. Tretyakova, N.F. Baranova, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 3, pp. 163–168.
Rights and permissions
About this article
Cite this article
Vlasova, O.S., Bichkaeva, F.A., Tretyakova, T.V. et al. Saturated Fatty Acids and Parameters of Carbohydrate Metabolism in Adolescents of sub-Arctic and Arctic regions. J Evol Biochem Phys 54, 185–191 (2018). https://doi.org/10.1134/S0022093018030031
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0022093018030031