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New Acylate and Thioacylate Effectors of Mammalian Cholinesterases Based on Cyclic Ammonium Alcohols Containing Elements of the Anabasine Structure

  • Comparative and Ontogenic Biochemistry
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Abstract

We report a pioneering analysis of the interaction between mammalian cholinesterases and 36 acylates and thioacylates of ammonium alcohols with different structure of an alkyl chain between ammonium and etheric atoms and with different structure of a cyclic ammonium group. Among these ethers, which were both substrates and reversible inhibitors of erythrocyte cholinesterase and serum butyrylcholinesterase, specific effectors of both enzymes were identified.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    N. E. Basova, B. N. Kormilitsyn, A. Yu. Perchenok, E. V. Rozengart, V. S. Saakov & A. A. Suvorov

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  1. N. E. Basova
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  2. B. N. Kormilitsyn
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  3. A. Yu. Perchenok
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  4. E. V. Rozengart
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  5. V. S. Saakov
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  6. A. A. Suvorov
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Correspondence to N. E. Basova.

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Original Russian Text © N.E. Basova, B.N. Kormilitsyn, A.Yu. Perchenok, E.V. Rozengart, V.S. Saakov, A.A. Suvorov, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 1, pp. 20—26.

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Basova, N.E., Kormilitsyn, B.N., Perchenok, A.Y. et al. New Acylate and Thioacylate Effectors of Mammalian Cholinesterases Based on Cyclic Ammonium Alcohols Containing Elements of the Anabasine Structure. J Evol Biochem Phys 54, 22–29 (2018). https://doi.org/10.1134/S0022093018010039

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  • DOI: https://doi.org/10.1134/S0022093018010039

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