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Regulation of destructive processes occurring in the body during senescence and in oncogenesis: A hypothesis

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A hypothesis has been put forward according to which destructive processes occurring in the body during senescence and in oncogenesis are regulated by an atavistic mechanism of apical dominance described by plant physiologists. This mechanism is inherited from the first on Earth metazoans that behaved the mode of life attached to benthos and to underwater objects and were modular.

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References

  1. Anisimov, V.N., Senescence and Carcinogenesis, Usp. Gerontol., 2002, no. 10, pp. 99–125.

    Google Scholar 

  2. Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Senescence), St. Petersburg, 2003.

    Google Scholar 

  3. Beklemishev, V.N., Osnovy sravnitel’noi anatomii bespozvonochnykh, T. 1, Promorfologiya (The Grounds of Comparative Anatomy of Invertebrates. vol. I. Promorphology), Moscow, 1964.

    Google Scholar 

  4. Zakhvatkin, A.A., Sravnitel’naya embriologiya nizshikh bespozvonochnykh (Istochniki i puti formirovaniya individualnogo razvitiya) (Comparative Embryology of Lower Invertebrates (Sources and Pathways of Formation of Individual Development)), Moscow, 1949.

    Google Scholar 

  5. Ivanova-Kazas, O.M., Bespoloe razmnozhenie zhivotnykh (Asexual Reproduction of Animals), Leningrad, 1977.

    Google Scholar 

  6. Makrushin, A.V. and Khudoley, V.V., Tumor as an Atavistic Adaptive Reaction to Environmental Conditions, Zh. Obsch. Biol., 1991, vol. 52, no. 5, pp. 717–722.

    CAS  Google Scholar 

  7. Makrushin, A.V., Diapause and Tumors, Zh. Evol. Biokhim. Fiziol., 1996, vol. 32, no. 5, pp. 650–655.

    PubMed  CAS  Google Scholar 

  8. Makrushin, A.V., Evolutionary Precursors of Oncogenesis and Senile Involution, Usp. Gerontol., 2004, no. 13, pp. 32–43.

    Google Scholar 

  9. Makrushin A.V., How and Why the Mechanisms of Senescence and Oncogenesis Arose: Hypothesis, Zh. Obsch. Biol., 2008, vol. 69, no. 1, pp. 19–24.

    CAS  Google Scholar 

  10. Marfenin, N.N., The Concept of Modular Organization, Zh. Obsch. Biol., 1999, vol. 60, no. 1, pp. 6–17.

    Google Scholar 

  11. Notov, A.A., On Specificity and Functional Organization of Individual Development in Modular Objects, Zh. Obsch. Biol., 1999, vol. 60, no. 1, pp. 60–79.

    Google Scholar 

  12. Orbeli, L.A., The Evolutionary Principle in Physiology (Problemy Sovetskoi fiziologii, biokhimii i farmakologii. VII Vses. s”ezd fiziologov, biokhimikov i farmakologov. Kniga pervaya (Problems of Soviet Physiology, Biochemistry and Pharmacology. VII All-Russ. Congress of Physiologists, Biochemists and Pharmacologists, The First Book), Moscow, 1949, pp. 8–13.

    Google Scholar 

  13. Ronzhina, E.S. and Mokronosov, A.T., The Donor-Acceptor Relations and Participation of Cytokines in Regulation of Transport and Distribution of Organic Substances in Plants, Fiziol. Rasten., 1994, vol. 41, no. 3, pp. 448–459.

    CAS  Google Scholar 

  14. Khudoley, V.V., Unsolved Problems and Perspectives of Comparative Oncology, Vopr. Onkol., 1992, vol. 38, no. 11, pp. 1345–1354.

    Google Scholar 

  15. Khudoley, V.V., Evolution, Ecology, Cancer, Eksper. Onkol., 1993, no. 2. pp. 7–20.

    Google Scholar 

  16. Jägersten, G., Evolution of the Metazoan Life Cycle. A Comprehensive Theory, London, New York, 1972.

    Google Scholar 

  17. Khudoley, V.V., Phylogenesis and Cancer: Unsolved Questions of Comparative and Evolutionary Oncology, Spontaneous Animal Tumors: A Survey, Rossi, L., Richardson, R., and Harshbarger, J., Eds., Genua, 1997, pp. 167–171.

    Google Scholar 

  18. Larsson, Sv.G., Reflection in the System Deuterostomia, Skrift. Unuv. Zool. Mus. København, 1963, vol. 20. pp. 5–128.

    Google Scholar 

  19. Makrushin, A.V., Senescence and Carcinogenesis as Atavistic Processes Inherited from Modular Ancestors: A Hypothesis, Adv. Gerontol., 2009, vol. 1, no. 1, pp. 45–49.

    Article  Google Scholar 

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Correspondence to A. V. Makrushin.

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Original Russian Text © A.V. Makrushin, 2013, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2013, Vol. 49, No. 3, pp. 239–241.

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Makrushin, A.V. Regulation of destructive processes occurring in the body during senescence and in oncogenesis: A hypothesis. J Evol Biochem Phys 49, 373–375 (2013). https://doi.org/10.1134/S0022093013030146

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  • DOI: https://doi.org/10.1134/S0022093013030146

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