Abstract
Using Perls’ histochemical method, iron was revealed in the brain structures of human and rat. Iron accumulation was observed in perivascular areas and neuropil of substantia nigra as well as in white matter of cerebellum. After diaminobenzidine enhancement of histochemical reaction, the iron was revealed in nucleoli of many neurons, which is described for the first time in animal cells.
References
Hankeln, T., Ebner, B., Fuchs, C., Gerlach, F., Haberkamp, M., Laufs, T.L., Roesner, A., Schmidt, M., Weich, B., Wystub, S., Saaler-Reinhardt, S., Reuss, S., Bolognesi, M., De Sanctis, D., Marden, M.C., Kiger, L., Moens, L., Dewilde, S., Nevo, E., Avivi, A., Weber, R.E., Fago, A., and Burmester, T., Neuroglobin and Cytoglobin in Search of Their Role in the Vertebrate Globin Family, J. Inorg. Biochem., 2005, vol. 99, no. 1, pp. 110–119.
Youdim, M.B., Stephenson, G., and Ben Shachar, D., Ironing Iron out in Parkinson’s Disease and Other Neurodegenerative Diseases with Iron Chelators: a Lesson from 6-Hydroxydopamine and Iron Chelators, Desferal and VK-28, Ann. N.Y. Acad. Sci., 2004, vol. 1012, pp. 306–325.
Benkovic, S.A. and Connor, J.R., Ferritin, Transferrin, and Iron in Selected Regions of the Adult and Aged Rat Brain, J. Comp. Neurol., 1993, vol. 338, pp. 97–113.
Korzhevskii, D.E., Grigoriev, I.P., and Otellin, V.A., Use of Zinc-Containing Dehydrating Fixatives for Neurohistological Studies, Morfologiya, 2006, vol. 129, no. 1, pp. 85–86.
Meguro, R., Asano, Y., Odagiri, S., Li, C., Iwatsuki, H., and Shoumura, K., Nonheme-Iron Histochemistry for Light and Electron Microscopy: a Historical, Theoretical and Technical Review, Arch. Histol. Cytol., 2007, vol. 70, no. 1, pp. 1–19.
Roschzttardtz, H., Grillet, L., Isaure, M.-P., Conéjéro, G., Ortega, R., Curie, C., and Mari, S., Plant Cell Nucleolus As a Hot Spot for Iron, J. Biol. Chem., 2011, vol. 286, no. 32, pp. 27 863–27 866.
Alkhateeb, A.A. and Connor, J.R., Nuclear Ferritin: a New Role for Ferritin in Cell Biology, Biochim. Biophys. Acta, 2010, vol. 1800, no. 8, pp. 793–797.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E.G. Sukhorukova, I.P. Grigoriev, O.V. Kirik, O.S. Alekseeva, D.E. Korzhevskii, 2013, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2013, Vol. 49, No. 3, pp. 236–238.
Rights and permissions
About this article
Cite this article
Sukhorukova, E.G., Grigoriev, I.P., Kirik, O.V. et al. Intranuclear localization of iron in neurons of mammalian brain. J Evol Biochem Phys 49, 370–372 (2013). https://doi.org/10.1134/S0022093013030134
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0022093013030134