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Cells in the system of multicelular organism from positions of non-linear dynamics


The organism physiological systems forming a hierarchic network with mutual dependence and subordination can be considered as systems with non-linear dynamics including positive and negative feedbacks. In the course of evolution there occurred selection of robust, flexible, modular systems capable for adaptive self-organization by non-linear interaction of components, which leads to formation of the ordered in space and time robust and plastic organization of the whole. Cells of multicellular organisms are capable for coordinated “social” behavior with formation of ordered cell assemblies, which provides a possibility of morphological and functional variability correlating with manifestations of the large spectrum of adaptive reactions. The multicellular organism is the multilevel system with hierarchy of numerous subsystems capable for adaptive self-organization; disturbance of their homeostasis can lead to pathological changes. The healthy organism regulates homeostasis, self-renewal, differentiation, and apoptosis of cells serving its parts and construction blocks by preserving its integrity and controlling behavior of cells. The systemic approach taking into account biological regularities of the appearance and development of functions in evolution of multicellular organisms opens new possibilities for diagnostics and treatment of many diseases.

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Correspondence to V. V. Isaeva.

Additional information

Original Russian Text © V.A. Kotolupov, V.V. Isaeva, 2012, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2012, Vol. 48, No. 5, pp. 517–526.

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Kotolupov, V.A., Isaeva, V.V. Cells in the system of multicelular organism from positions of non-linear dynamics. J Evol Biochem Phys 49, 262–273 (2013).

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Key words

  • homeostasis
  • non-linear dynamics
  • self-organization