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On epigenetic regulation of the process of formation of long-term memory

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Abstract

The review summarizes current concepts on the role of several covalent post-translational chromatin modifications during memory formation in vertebrates and invertebrates. It describes a sequence of intracellular events from activation of receptors and signal pathways up to changes in the functional state of genome.

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Abbreviations

BDNF:

brain-derived neurotrophic factor

CBP:

CREB-binding protein

CREB:

cAMP responsive element binding protein

DNMT:

DNA methyltransferase

DNMT1:

DNA methyltransferase 1

DNMT3a:

DNA methyltransferase 3a

DNMT3b:

DNA methyltransferase 3b

EHMT:

euchromatin histone methyltransferase

Elk1:

E twenty-six (ETS)-like transcription factor 1

ERK:

extracellular signal-regulated kinase

H3S10ph:

histone H3 serine 10 phosphorylation

H3K4me:

histone H3 lysine 4 methylation

H3K9me:

histone H3 lysine 9 methylation

HAT:

histone-acetyltransferase

HDAC:

histone-deacetylase

HDAC2:

histone-deacetylase 2

Lys:

lysine

MAPK:

mitogen-activated protein kinase

MBD1:

methyl-CpG binding protein

Msk1:

mitogen- and stress-activated protein kinase 1

NMDA:

N-methyl-D-aspartate

PKA:

protein kinase A

PKC:

protein kinase C

PP1:

protein phosphatase 1

RSTS:

Rubinstein-Taybi syndrome

Ser:

serine

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  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. V. Shvetsov, T. G. Zachepilo, A. I. Vaido, N. G. Kamyshev & N. G. Lopatina

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  1. A. V. Shvetsov
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  2. T. G. Zachepilo
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Original Russian Text © A.V. Shvetsov, T.G. Zachepilo, A.I. Vaido, N.G. Kamyshev, N.G. Lopatina, 2013, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2013, Vol. 49, No. 2, pp. 97–104.

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Shvetsov, A.V., Zachepilo, T.G., Vaido, A.I. et al. On epigenetic regulation of the process of formation of long-term memory. J Evol Biochem Phys 49, 129–137 (2013). https://doi.org/10.1134/S0022093013020011

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