The evolutionarily conservative 2,5-dimethylpyrazine chemosignal, a pheromone released by female mice, has been shown to increase frequency of mitotic disturbances in bone marrow cells assessed by using metaphase and ana-telophase analyses. The substitution of methyl radical in the molecule of pheromone by carboxyl reveals specificity of the effect of the latter derivative: the frequency of disturbances revealed by the ana-telophase analysis alone increases, whereas no induction of disturbance is detected by the metaphase analysis. An increase of the anomalies induced by both compounds has been shown in a sperm head test. Possible mechanisms underlying specific action of the tested substances on stability of the genetic apparatus of bone marrow dividing cells in the house mouse are discussed.
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Original Russian Text © E. V. Daev, A. M. Vyborova, V. E. Kazarova, A. V. Dukel’skaya, 2012, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2012, Vol. 48, No. 1, pp. 17–21.
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Daev, E.V., Vyborova, A.M., Kazarova, V.E. et al. Effect of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mice (Mus musculus L.). J Evol Biochem Phys 48, 18–23 (2012). https://doi.org/10.1134/S0022093012010033