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Effect of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mice (Mus musculus L.)

Journal of Evolutionary Biochemistry and Physiology volume 48, pages 18–23 (2012)Cite this article

Abstract

The evolutionarily conservative 2,5-dimethylpyrazine chemosignal, a pheromone released by female mice, has been shown to increase frequency of mitotic disturbances in bone marrow cells assessed by using metaphase and ana-telophase analyses. The substitution of methyl radical in the molecule of pheromone by carboxyl reveals specificity of the effect of the latter derivative: the frequency of disturbances revealed by the ana-telophase analysis alone increases, whereas no induction of disturbance is detected by the metaphase analysis. An increase of the anomalies induced by both compounds has been shown in a sperm head test. Possible mechanisms underlying specific action of the tested substances on stability of the genetic apparatus of bone marrow dividing cells in the house mouse are discussed.

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Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, Russia

    E. V. Daev, A. M. Vyborova, V. E. Kazarova & A. V. Dukel’skaya

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  1. E. V. Daev
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  2. A. M. Vyborova
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  3. V. E. Kazarova
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  4. A. V. Dukel’skaya
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Correspondence to E. V. Daev.

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Original Russian Text © E. V. Daev, A. M. Vyborova, V. E. Kazarova, A. V. Dukel’skaya, 2012, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2012, Vol. 48, No. 1, pp. 17–21.

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Daev, E.V., Vyborova, A.M., Kazarova, V.E. et al. Effect of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mice (Mus musculus L.). J Evol Biochem Phys 48, 18–23 (2012). https://doi.org/10.1134/S0022093012010033

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  • DOI: https://doi.org/10.1134/S0022093012010033

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