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Effect of change in levels of motor activity and innervation on basic and secondary rhythms of rat heart beatings and respiration in ontogenesis

  • Comparative and Ontogenic Physiology
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Abstract

Changes in the heart basic rhythm, its rhythmical variations on periodograms, and level of spontaneous motor activity were studied on offspring of white rats from newborn to 3-week age at transition from the state of active wakefulness to narcosis as well as under conditions of blockade of M-cholinoreceptors with atropine. It is shown that the endogenous rhythmical activity can be regulated not only by a change in frequency of basic rhythms, but also by action on all parameters and properties of their rhythmical variations and secondary rhythms. The changes in power of the heart secondary rhythms exceed considerably the frequency oscillations of basic rhythms during blockade of cholinergic innervation or a change in the motor activity level that affects both the basic rhythm circulation and respiration and their variations—secondary rhythms. The atropine blockade of M-cholinoreceptors at the studied ages changes the heart contraction rhythm within the limits of 10% of bradycardia in newborns to tachycardia in the 3-week old animals. At the same time, power of the cardiac rhythm secondary oscillations changes several times. These data indicate that the cholinergic mechanisms play the key role in formation of the secondary rhythms and their correlation with motor activity.

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References

  1. Kulaev, B.S., Bursian, A.V., Timofeeva, O.P., Dmitrieva, L.E., Polyakova, L.A., and Semenova, Yu.O., Rhythmic Processes in Developing Organism and Forms of Its Coordination, Zh. Evol. Biokhim. Fiziol., 1999, vol. 35, pp. 368–375.

    PubMed  CAS  Google Scholar 

  2. Bursian, A.V., Organization of Endogenous Rhythms of Motor Functions, Zh. Evol. Biokhim. Fiziol., 2009, vol. 45, pp. 547–552.

    PubMed  CAS  Google Scholar 

  3. Bursian, A.V., Development of Ontogenetic Method in Study of Evolution of Contractile Functions, Zh. Evol. Biokhim. Fiziol., 2002, vol. 38, pp. 485–491.

    PubMed  CAS  Google Scholar 

  4. Bursian, A.V., Dmitrieva, L.E., and Sizonov, Yu.O., The Secondary Rhythm of the Autorhyth mically Functioning Systems, Zh. Evol. Biokhim. Fiziol., 2009, vol. 45, pp. 553–558.

    PubMed  CAS  Google Scholar 

  5. Belich, A.I. and Konstantinova, N.N., Formation of Coordination Function of the Central Nervous System: Phylo- and Ontogenetic Aspects, Zh. Evol. Biokhim. Fiziol., 2003, vol. 39, pp. 297–306.

    PubMed  CAS  Google Scholar 

  6. Bursian, A.V., Dmitrieva, L.E., Polyakova, L.A., and Sizonov, Yu.O., Interrelations of Somatomotor Excitation and Heart Activity in Developing Rats, Zh. Evol. Biokhim. Fiziol., 2004, vol. 40, pp. 147–152.

    PubMed  CAS  Google Scholar 

  7. Polyakova, L.A., Dmitrieva, L.E., and Bursian, A.V., Establishment of Cardiomotor Interrelations in Rat Ontogenesis, Zh. Evol. Biokhim. Fiziol., 2006, vol. 42, pp. 359–364.

    Google Scholar 

  8. Timofeeva, O.P., Bursian, A.V., Sizonov, Yu.O., and Vdovichenko, N.D., Peculiarities of Regulation of High-Frequency Oscillations of the Heart Rhythm in Rat Ontogenesis, Zh. Evol. Biokhim. Fiziol., 1999, vol. 35, pp. 87–98.

    Google Scholar 

  9. Bursian, A.V., Sizonov, V.A., Semenova, Yu.O., and Kulaev, B.S., Role of Sympathetic and Parasympathetic Mechanisms in Formation of Secondary Heart Rhythms, Zh. Evol. Biokhim. Fiziol., 2005, vol. 41, pp. 69–75.

    Google Scholar 

  10. Syutkina, E.V., Effect of Blockade of Cholinoreceptors and β-Adrenoreceptors on Variability of Heart Rhythm of Rat Embryos, Vestn. AMN, 1985, no. 6, pp. 31–35.

  11. Cyevai, A., Comparative Investigation Concerning Prenatal and Postnatal Cholinesterase Activity in the Heart of Chickens and Rats, Acta Biol. Acad. Sci. Hung., 1969, vol. 20,pp. 253–262.

    Article  Google Scholar 

  12. Hall, E.K., Acetylcholine and Epinephrine Effects on the Embryonic Rat Heart, J. Cell. Comp. Physiol., 1957, vol. 49, pp. 187–200.

    Article  CAS  Google Scholar 

  13. Adolf, E.F., Origin of Physiological Regulations, N.Y., London, 1968.

    Google Scholar 

  14. Kasparov, S. and Paton, J.F., Changes in Baroreceptor Vagal Reflex Performance in the Developing Rat, Eur. J. Physiol., 1997, vol. 434, pp. 438–444.

    Article  CAS  Google Scholar 

  15. Timofeeva, O.P. and Vdovichenko, N.D., Study of the Cardiac, Respiratory, and Motor Activities in Rat Embryos, Zh. Evol. Biokhim. Fiziol., 2009, vol. 45, pp. 559–566.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    A. V. Bursian, L. E. Dmitrieva & V. A. Sizonov

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  1. A. V. Bursian
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  2. L. E. Dmitrieva
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  3. V. A. Sizonov
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Additional information

Original Russian Text © A. V. Bursian, L. E. Dmitrieva, V. A. Sizonov, 2011, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2011, Vol. 47, No. 4, pp. 311–317.

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Bursian, A.V., Dmitrieva, L.E. & Sizonov, V.A. Effect of change in levels of motor activity and innervation on basic and secondary rhythms of rat heart beatings and respiration in ontogenesis. J Evol Biochem Phys 47, 366–373 (2011). https://doi.org/10.1134/S0022093011040086

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  • DOI: https://doi.org/10.1134/S0022093011040086

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