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Effect of total hypothermia on the fatty acid composition of blood phospholipids of rats and ground squirrels and of the light irradiation on chemical processes in lipid extract

  • Comparative and Ontogenic Biochemistry
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Abstract

Effect of hypothermia on the fatty acid composition of rat and ground squirrel blood phospholipids is studied. Different reaction of these animals to cooling is revealed; in rats no changes were observed in the fatty acid composition of blood phospholipids, whereas in the winterhibernating ground squirrels there were significant changes in the content of individual fatty acids (FA). The content of monoenic acids in ground squirrels decreased almost by 50%, while the content of saturated acid (C18) and of polyenic acids C18: 2ω6 and C20: 4ω6 rose significantly. Such changes seem to be the mechanism that promotes maintenance of the organism viability under conditions of a decreased level of metabolism, heart rhythm, and body temperature and is evolutionary acquired. At the same time, the observed changes in the content of individual FA do not lead to sharp changes in such integrative parameters as the total non-saturation of phospholipids, which determines liquid properties of chylomicrons and other lipolipoprotein transport particles of the ground squirrel blood. There are studied absorption spectra of blood lipid extracts of rats and ground squirrels under effect of light as well as effect of light upon the FA composition of lipid extracts of these animals. The FA composition of lipid extracts has been established to remain practically constant, whereas the character of changes of spectra under action of light indicates the presence in the extracts of oxidation-reduction reactions. The obtained data allow suggesting that in the lipid extract there occurs cooperation of both the phospholipids molecules themselves and of them with other organic molecules, which makes it possible for fatty acids to participate in processes of transport both of electrons and of protons. This novel role of FA as a participant of the electron transfer might probably be extrapolated to chemical reactions (processes) occurring inside the membrane.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    S. A. Zabelinskii, M. A. Chebotareva, A. I. Krivchenko & A. M. Kazennov

  2. Dagestan State University, Makhach-Kala, Republic of Dagestan, Russia

    A. M. Kalandarov, B. A. Feizulaev & N. K. Klichkhanov

Authors
  1. S. A. Zabelinskii
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  2. M. A. Chebotareva
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  3. A. M. Kalandarov
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  4. B. A. Feizulaev
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  5. N. K. Klichkhanov
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  6. A. I. Krivchenko
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  7. A. M. Kazennov
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Correspondence to A. M. Kazennov.

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Original Russian Text © S. A. Zabelinskii, M. A. Chebotareva, A. M. Kalandarov, B. A. Feizulaev, N. K. Klichkhanov, A. I. Krivchenko, A. M. Kazennov, 2011, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2011, Vol. 47, No. 4, pp. 283–289.

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Zabelinskii, S.A., Chebotareva, M.A., Kalandarov, A.M. et al. Effect of total hypothermia on the fatty acid composition of blood phospholipids of rats and ground squirrels and of the light irradiation on chemical processes in lipid extract. J Evol Biochem Phys 47, 333–340 (2011). https://doi.org/10.1134/S0022093011040049

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  • DOI: https://doi.org/10.1134/S0022093011040049

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