Abstract
Restriction of protein in nutrition of rat pups weaned at different terms has been found to produce changes in activities of digestive enzymes (maltase, alkaline phosphatase, aminopeptidase M, and glycyl-L-leucine dipeptidase) in the small and large intestine both at once after cessation of nutrition with low-protein diet for 10 days and 4 months later. In adult animals after the earlier or later weaning there are observed not only a decrease or increase of the enzyme activities, but also a different type of distribution of the alkaline phosphatase activity along the small intestine, which is more pronounced in the lately weaned rats. Thus, disturbance of metabolic programming of enzyme systems of the small and large intestine due to a change of quality of nutrition in early ontogenesis depends on terms of weaning of animals.
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Ugolev, A.M., de Laey, P., Iezuitova, N.N., Rakhimov, K.R., Timofeeva, N.M., and Stepanova, A.T., Membrane Digestion and Nutrient Assimilation in Early Development, Development of Mammalian Absorptive Processes, Ciba Found. Symp. 70, Elliott, K. and Whelan, J., Eds., Amsterdam: Excerpta Medica, 1979, p. 23.
Lee, P.C. and Lebenthal, E., Early Weaning and Precocious Development of Small Intestine in Rats: Genetic, Dietary or Hormonal Control, Pediatr. Res., 1983, vol. 17, pp. 645–650.
Koldovsky, O., Development of Human Gastrointestinal Functions; Interaction of Changes in Diet Composition, Hormonal Maturation, and Fetal Programming, J. Amer. College Nutr., 1984, vol. 3, pp. 131–138.
Kretchmer, N., Weaning: Enzymatic Adaptation, Amer. J. Clin. Nutr., 1985, vol. 41, pp. 391–398.
Rakhimov, K.R., Mekhanizmy usvoeniya laktozy v ontogeneze cheloveka i zhivotnykh (Mechanisms of the Lactose Assimilation in Human and Animal Ontogenesis), Tashkent, 1991.
Herming, S.J., Rubin, D.C., and Shulman, R.J., Ontogeny of the Intestinal Mucosa, Physiology of the Gastrointestinal Tract, Johnson, L.R., Ed., New York: Raven, 1994. p. 39.
Timofeeva, N.M., Maturation of Intestinal Digestive Enzymes in Ontogenesis, Fiziol. Zh. im. I.M. Sechenova, 1995, vol. 81, pp. 1–18.
Egorova, V.V., Nikitina, A.A., and Timofeeva, N.M., Functioning of Enzyme Systems of Digestive and Non-Digestive Organs in Adult Rats Depends on the Nutrition Quality in Early Ontogenesis, Zh. Evol. Biokhim. Fiziol., 2005, vol. 41, pp. 514–519.
Gama, P. and Alvares, E.P., Early Weaning and Prolonged Nursing Induce Changes in Cell Proliferation in the Gastric Epithelium of Developing Rats, J. Nutr., 2000, vol. 130, pp. 2594–2598.
Pacha, J., Development of Intestinal Transport Function in Mammals, Physiol. Rev., 2000, vol. 80, pp. 1633–1667.
Morgan, J.B., Lucas, A., and Fewtrell, M.S., Does Weaning Influence Growth and Health up to 18 Months?, Arch. Dis. Child., 2004, vol. 89, pp. 728–733.
Fortman, J.K., Reichling, T., and German, R.Z., The Impact Maternal Protein Malnutrition on Preweaning Skeletal and Visceral Organ Growth in Neonatal Offspring of Rattus norvegicus, Growth Dev. Aging, 2005, vol. 69, pp. 39–52.
Velkoska, E., Cole, T.J., and Morris, M.J., Early Dietary Intervention: Long-Term Effects on Blood Pressure, Brain Neuropeptide Y, and Adiposity Markers, Am. J. Physiol., Endocrinol. Metab., 2005, vol. 288, no. 6, pp. E1236–E1243.
Vataeva, L.A., Egorova, V.V., Kassil, V.G., Makukhina, G.V., Nikitina, A.A., and Timofeeva, N.M., Delayed Effects of Time of Weaning and Conditions of Post-Weaning Maintenance on Digestive Enzymes in Rats, Ernahrungsforsch., 1998, vol. 43, no. 1, pp. 1–6.
Kassil’, V.G., Egorova, V.V., Nikitina, A.A., Gordova, L.A., Vataeva, L.A., Makukhina, G.V., Timofeeva, N.M., and Filaretova, L.P., Activity of Digestive Enzymes in Rats Weaned at Different Terms from Lactating Females in the Absence or on the Background of Stress, Zh. Evol. Biokhim. Fiziol., 2000, vol. 36, pp. 304–309.
Timofeeva, N.M., Metabolic/Nutritional Program of Enzyme Systems of the Offspring Small Intestine, Ross. Fiziol. Zh. im. I.M. Sechenova, 2000, vol. 86, pp. 1531–1538.
Membrannyi gidroliz i transport. Novye dannye i gipotezy (Membrane Hydrolysis and Transport. New Data and Hypotheses, Ugolev, A.M., Ed., Leningrad, 1986.
Desai, M., Crowter, N.J., Lucas, A., and Hales, C.N., Organ-Selective Growth in the Offspring of Protein-Restricted Mothers, Brit. J. Nutr., 1996, vol. 76, pp. 591–603.
Duluc, I., Galluser, M., Raul, F., and Freund, J. N., Dietary Control of the Lactase mRNA Distribution along the Rat Small Intestine, Am. J. Physiol., 1992, vol. 262, pp. G954–G961.
Adaptatsionno-compensatornye protsessy. Na primere membrannogo gidroliza i transporta (Adaptational-Compensatory Processes. By Example of the Membrane Hydrolysis and Transport), Ugolev, A.M., Ed., Leningrad, 1991.
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Original Russian Text © V. V. Egorova, A. A. Nikitina, N. M. Timofeeva, 2008, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2008, Vol. 44, No. 5, pp. 501–507.
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Egorova, V.V., Nikitina, A.A. & Timofeeva, N.M. Effect of weaning terms and protein deficit in rat pup nutrition on activities of digestive enzymes. J Evol Biochem Phys 44, 591–598 (2008). https://doi.org/10.1134/S0022093008050083
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DOI: https://doi.org/10.1134/S0022093008050083