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Comparative analysis of sensitivity of cholinesterases to reversible inhibitors by methods of multidimensional statistics

  • Comparative and Ontogenic Biochemistry
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Abstract

Using the methods of factor and cluster analysis, the statistical treatment is performed of data on interaction of seven cholinesterases (ChE)—human acetylcholinesterase, horse butyrylcholinesterase, cholinesterases of frog brain and of different squid species (Todarodes pacificus and Berrytheutis magister, in the latter case, individuals from three different habitats are compared)—with 141 reversible inhibitors of various structures. Statistically significant differences between ChE of squids and vertebrates are shown. The previously revealed intraspecies peculiarities of ChE in the Commander squid B. magister are statistically confirmed.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    S. N. Moralev & A. Yu. Perchenok

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  1. S. N. Moralev
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  2. A. Yu. Perchenok
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Original Russian Text © S. N. Moralev, A. Yu. Perchenok, 2008, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2008, Vol. 44, No. 5, pp. 488–491.

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Moralev, S.N., Perchenok, A.Y. Comparative analysis of sensitivity of cholinesterases to reversible inhibitors by methods of multidimensional statistics. J Evol Biochem Phys 44, 576–580 (2008). https://doi.org/10.1134/S002209300805006X

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  • DOI: https://doi.org/10.1134/S002209300805006X

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