Abstract
Comparative study of radioprotective properties of venoms of the honeybee Apis mellifera, salamander Salamandra salamandra, and toad Bufo viridis was performed on a model of the bone marrow form of radiation disease in rats. It has been revealed that after repeated administrations at low doses, all studied venoms produce radioprotective effect. The state of radioresistance has been established to remain for 4 weeks after the end of the venom administration. It has been shown that the revealed effects are mainly due to the venom-produced development of unspecific adaptational reaction—the activation reaction that, unlike stress, is accompanied by development of active resistance. The present study allows ascribing the honeybee, salamander, and toad venoms to long-acting radioprotectors.
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Original Russian Text © V. N. Krylov, A. S. Koryagin, E. A. Erofeeva, 2008, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2008, Vol. 44, No. 4, pp. 424–428.
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Krylov, V.N., Koryagin, A.S. & Erofeeva, E.A. Comparative analysis of radioprotective properties of some zootoxins. J Evol Biochem Phys 44, 501–506 (2008). https://doi.org/10.1134/S002209300804011X
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DOI: https://doi.org/10.1134/S002209300804011X