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Signaling pathway of insulin and insulin-like growth factor 1 (IGF-1) as a potential regulator of lifespan

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Abstract

The experimental material accumulated for two decades allows concluding that regulation of lifespan has hormonal control based on the evolutionary conservative insulin/IGF-1 receptor signaling pathway. Data obtained on the commonly accepted models of longevity — nematode Caenorhabditis elegans, fruit fly Drosophila melanogaster, and rodents — demonstrate that reduction of the insulin/IGF-1 signaling pathway results in an increase of the lifespan. There is shown involvement in the longevity mechanism of a large group of genes whose products perform control of metabolism, feeding behavior, reproduction, and resistance to oxidative stress. Discussed in this review are current concepts of the insulin/IGF-1 signaling system as a regulatory “longevity module” and of its possible role in prolongation of life in the higher vertebrates, including human.

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  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    O. V. Chistyakova

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Original Russian Text © O.V. Chistyakova, 2008, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2008, Vol. 44, No. 1, pp. 3–11.

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Chistyakova, O.V. Signaling pathway of insulin and insulin-like growth factor 1 (IGF-1) as a potential regulator of lifespan. J Evol Biochem Phys 44, 1–11 (2008). https://doi.org/10.1134/S0022093008010015

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