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NUMERICAL SIMULATION OF THE INFLAMMATORY PHASE OF MYOCARDIAL INFARCTION

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Journal of Applied Mechanics and Technical Physics Aims and scope

Abstract

The dynamics of death of cardiac muscle cells in the acute phase of myocardial infarction is studied numerically. The problem is considered in local and spatially distributed formulations. The adequacy of the mathematical model is confirmed by the quantitative agreement between the results of numerical solution of the problem and experimental data. The adopted models are used to investigate the trigger mechanism of transition from a favorable scenario for the development of acute myocardial infarction to a scenario with a rapid increase in the level of myocardial damage on the third–fifth day of myocardial infarction. For these scenarios of the development of myocardial infarction, the process of demarcating inflammation is investigated. The results of the studies, including evaluations of the effectiveness of anti-inflammatory cytokine therapeutic strategies, are consistent with available data of laboratory studies.

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Authors and Affiliations

  1. Federal Research Center for Information and Computational Technologies, 630090, Novosibirsk, Russia

    O. F. Voropaeva, Ch. A. Tsgoev & Yu. I. Shokin

  2. Novosibirsk National Research State University, 630090, Novosibirsk, Russia

    Ch. A. Tsgoev

Authors
  1. O. F. Voropaeva
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  2. Ch. A. Tsgoev
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  3. Yu. I. Shokin
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Corresponding author

Correspondence to O. F. Voropaeva.

Additional information

Translated from Prikladnaya Mekhanika i Tekhnicheskaya Fizika, 2021, Vol. 62, No. 3, pp. 105-117. https://doi.org/10.15372/PMTF20210310.

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Voropaeva, O.F., Tsgoev, C.A. & Shokin, Y.I. NUMERICAL SIMULATION OF THE INFLAMMATORY PHASE OF MYOCARDIAL INFARCTION. J Appl Mech Tech Phy 62, 441–450 (2021). https://doi.org/10.1134/S002189442103010X

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  • DOI: https://doi.org/10.1134/S002189442103010X

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