Abstract
Six thermo-activated transient receptor potential (TRP) channels are the molecular basis of the thermosensation for mammals. However, the molecular source of their gating remains unknown. In the Letter, we suggest a physically based model for the TRP channels and show that the temperature dependence of the “internal friction” can be a key factor governing the ion channels gating. Results of the computer modeling allowed us to successfully reproduce the experimental data for the open probability Popen of the TRPV1 and TRPM8 channels at different temperatures and voltages.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. E. Clapham, Nature (London, U.K.) 426, 517 (2003).
T. Voets and B. J. Nilius, Membr. Biol. 192, 1 (2003).
T. Voets, in Reviews of Physiology, Biochemistry and Pharmacology, Ed. by B. Nilius, S. G. Amara, T. Gudermann, R. Jahn, R. Lill, S. Offermanns, and O. H. Petersen (Springer, Berlin, Heidelberg, 2012), Vol. 162, p. 91.
T. Voets, G. Droogmans, U. Wissenbach, A. Janssens, V. Flockerzi, and B. Nilius, Nature (London, U.K.) 430, 748 (2004).
B. Liu, K. Hui, and F. Qin, Biophys. J. 85, 2988 (2003).
J. Yao, B. Liu, and F. Qin, Proc. Natl. Acad. Sci. U.S.A. 108, 11109 (2011).
D. E. Clapham and C. Miller, Proc. Natl. Acad. Sci. U.S.A. 108, 19492 (2011).
A. A. Rauscher, Z. Simon, G. J. Szollosi, L. Graf, I. Derenyi, and A. Malnasi-Csizmadia, FASEB J. 25, 2804 (2011).
A. S. Moskvin, B. I. Iaparov, A. M. Ryvkin, O. E. Solovyova, and V. S. Markhasin, JETP Lett. 102, 62 (2015).
R. Sitsapesan, R. A. Montgomery, K. T. MacLeod, and A. J. Williams, J. Physiol. 434, 469 (1991).
A. S. Moskvin, Tech. Phys. 63, 1277 (2018).
D. J. Wales, J. Chem. Phys. 142, 130901 (2015).
R. B. Best and G. Hummer, Proc. Natl. Acad. Sci. U.S.A. 107, 1088 (2010).
L. E. Kon’kov, T. L. Chizhova, Y. V. Koudryashova, and V. M. Chudnovsky, Nelin. Din. 4, 181 (2008).
F. J. Sigworth, Q. Rev. Biophys. 27, 1 (1994).
C. F. Stevens, Biophys. J. 22, 295 (1978).
P. Hanggi, P. Talkner, and M. Borkovec, Rev. Mod. Phys. 62, 251 (1990).
H. Risken, The Fokker-Planck Equation: Methods of Solution and Applications, Ed. by H. Haken (Springer, Berlin, Heidelberg, 1996).
M. P. Philipiev, Cand. Sci. (Phys. Math.) Dissertation (Ural State Univ., Yekaterinburg, 2007).
E. Vanden-Eijnden and G. Ciccotti, Chem. Phys. Lett. 429, 310 (2006).
Funding
This work was supported by the Government of the Russian Federation (agreement no. 02.A03.21.0006, Act 211) and by the Ministry of Education and Science of the Russian Federation (project nos. 2277 and 5719).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Okenov, A.O., Iaparov, B.I. & Moskvin, A.S. Internal Friction as a Possible Key Factor Governing the Thermosensitivity of TRP Channels. Jetp Lett. 110, 231–236 (2019). https://doi.org/10.1134/S0021364019150049
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0021364019150049