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Macroporous Calcium Phosphate Matrices Prepared Using the Technology of Self-Setting Cements

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Abstract—

We have developed a method for the preparation of macroporous carbonate hydroxyapatite-based matrices with the use of the technology of self-setting cements for surgical osteology. Macroporosity of osteoconductive calcium phosphate matrices was produced by adding paraffin granules to a dry cement mixture, followed by organic solvent extraction of the granules from matrices hydrated in an aqueous solution. In vivo tests of the resultant materials demonstrated high biocompatibility with pronounced angiogenesis, which was achieved via additional treatment with supercritical carbon dioxide.

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ACKNOWLEDGMENTS

We are grateful to our colleagues at LLC IPK Lik for technical assistance.

Funding

This work was supported by the Russian Foundation for Basic Research, project no. 18-29-06010.

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Authors and Affiliations

  1. Mendeleev University of Chemical Technology, 125047, Moscow, Russia

    Yu. S. Lukina

  2. Priorov National Medical Research Center of Traumatology and Orthopedics, 127299, Moscow, Russia

    Yu. S. Lukina, V. V. Zaitsev & N. S. Gavryushenko

  3. Moscow State University, 119991, Moscow, Russia

    L. V. Erkhova, D. P. Krut’ko & D. A. Lemenovskii

Authors
  1. Yu. S. Lukina
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  2. V. V. Zaitsev
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  3. L. V. Erkhova
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  4. D. P. Krut’ko
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  5. N. S. Gavryushenko
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  6. D. A. Lemenovskii
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Correspondence to Yu. S. Lukina.

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Lukina, Y.S., Zaitsev, V.V., Erkhova, L.V. et al. Macroporous Calcium Phosphate Matrices Prepared Using the Technology of Self-Setting Cements. Inorg Mater 57, 78–85 (2021). https://doi.org/10.1134/S0020168521010106

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  • DOI: https://doi.org/10.1134/S0020168521010106

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