Abstract
Calcium hydrogen phosphate dihydrate and amorphous calcium phosphate have been synthesized in an aqueous suspension of medium molecular weight chitosan in the presence of glutamic or aspartic acid. X-ray diffraction and transmission and scanning electron microscopy characterization showed that the morphology of the phases present depended on the nature of the amino acid. The amino acids participate in the protonation of the amino groups of the chitosan and, probably, in the formation of chelate intermediate compounds with calcium ions, which act as calcium phosphate nucleation centers.
Similar content being viewed by others
References
Barinov, S.M., Calcium-phosphate-based ceramic and composite materials for medical applications, Usp. Khim., 2010, vol. 79, pp. 15–32.
Chernetskii, V.N. and Nifant’ev, N.E., RF Patent 2 124 524, 1999.
Fadeeva, I.V., Barinov, S.M., Fedotov, A.Yu., and Komlev, V.S., Interactions of calcium phosphates with chitosan, Dokl. Chem., 2011, vol. 441, no. 2, pp. 387–390.
Zhu, Zh., Tong, H., Jiang, T., and Shen, X., Studies on induction of L-aspartic acid modified chitosan to crystal growth of the calcium phosphate in supersaturated calcification solution by quartz crystal microbalance, Biosens. Bioelectron., 2006, vol. 22, pp. 291–297.
Fedotov, A.Yu., Fadeeva, I.V., Barinov, S.M., et al., Synthesis of calcium phosphates on chitosan macromolecules in the presence of amino acids, Dokl. Chem., 2013, vol. 451, no. 2, pp. 207–210.
Shujun, S., Xinge, Z., Dayong, T., Zhen, W., et al., Polyelectrolyte nanoparticles based on water-soluble chitosan-poly(L-aspartic acid)-polyethylene glycol for controlled protein release, Carbohydr. Res., 2009, vol. 344, pp. 1197–1204.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © S.M. Barinov, A.A. Egorov, V.S. Komlev, I.V. Fadeeva, A.Yu. Fedotov, 2014, published in Neorganicheskie Materialy, 2014, Vol. 50, No. 7, pp. 757–760.
Rights and permissions
About this article
Cite this article
Barinov, S.M., Egorov, A.A., Komlev, V.S. et al. In situ synthesis of calcium phosphates on chitosan macromolecules in the presence of glutamic and aspartic acids. Inorg Mater 50, 703–706 (2014). https://doi.org/10.1134/S0020168514070036
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0020168514070036