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Interaction study between drugs and some synthetic nanoporous composites

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Abstract

In this work MCM-41, MCM-41/NaY and Clinoptilolite/MCM-41/NaY composites that have CTMABr (N-cethyl-N,N, and N-trimethyl Ammonium Bromide) were prepared and characterized with XRD, SEM and FT-IR. Also, incorporation of two model drugs (sulfamethoxazole and metronidazole) with these composite were considered. The drug adsorption assays showed that three composites adsorb considerable amount of drugs, in particular sulfamethoxazole which was evaluated by UV spectroscopy. The results show that we have more adsorption of sulfamethoxazole for MCM-41/NaY that there is a direct relationship exists between the amounts of surfactant per gram of composite. TGA shows that the composites are more stable thermally when the ad micelles contain sulfamethoxazole in their interior. The results of adsorption of sulfamethoxazole showed that approximately 70% of drug was released from MCM-41/NaY-sulfamethoxazole system after about 24 h.

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Authors and Affiliations

  1. Department of Chemistry, College of Science, Arak University, Arak, Iran

    M. Zendehdel & H. Alikhani

  2. Departments of Chemistry, Shahid Beheshti University, Tehran, Iran

    M. M. Pouramini

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  1. M. Zendehdel
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  2. M. M. Pouramini
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  3. H. Alikhani
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Correspondence to M. Zendehdel.

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Zendehdel, M., Pouramini, M.M. & Alikhani, H. Interaction study between drugs and some synthetic nanoporous composites. Inorg Mater 47, 80–86 (2011). https://doi.org/10.1134/S002016851101016X

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  • DOI: https://doi.org/10.1134/S002016851101016X

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