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Evaluation of the Applicability of External X-ray Radiation to Stimulate the Autoradiolysis Processes in Therapeutic Radiopharmaceuticals (Exemplified by [153Sm]Sm-PSMA-617 and [177Lu]Lu-PSMA-617)

  • RADIATION CHEMISTRY
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An Erratum to this article was published on 17 May 2023

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Abstract

The paper presents the results of a study on the radiolytic degradation of vector molecules in radiopharmaceuticals, caused by ionizing radiation from the radionuclide used in the preparations, in comparison with the equal dose of external X-ray irradiation. The dose factors for therapeutic radionuclides samarium-153 and lutetium-177 in aqueous solutions were estimated in geometry simulating the finished dosage form of radiopharmaceuticals (standard injection vial ) both by computational methods (in silico) and applying chemical dosimetry. Irradiation with external X-ray source to doses formed in volume of therapeutic radiopharmaceuticals with given radioactivity concentration was performed on an LNK-268 X-ray unit. Using the [153Sm]Sm-PSMA-617 and [177Lu]Lu-PSMA-617 radiopharmaceuticals as an instance, we compared the degree of radiolytic degradation and the profiles of radiolytic impurities formed as a result of both external X-ray irradiation and autoradiolysis. Qualitative coincidence of the impurity profiles formed in both cases was noted. It has been shown that external X-ray radiation can be used to simulate the autoradiolysis processes of radiopharmaceuticals if additional corrections are made for the type of radiation and dose rate.

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Notes

  1. In all experiments, the volumes of solutions were 1 mL (standard injection vial, r = 10 mm, h ≈ 3.2 mm).

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Funding

The work was carried out within the state assignment of the Federal Medicobiological Agency of Russia, project no. 122031100121-4.

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  1. State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098, Moscow, Russia

    Yu. A. Mitrofanov, V. B. Bubenshchikov, A. V. Belousov, A. S. Lunev & A. A. Larenkov

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  1. Yu. A. Mitrofanov
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  2. V. B. Bubenshchikov
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Correspondence to A. A. Larenkov.

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Translated by S. Zatonsky

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Mitrofanov, Y.A., Bubenshchikov, V.B., Belousov, A.V. et al. Evaluation of the Applicability of External X-ray Radiation to Stimulate the Autoradiolysis Processes in Therapeutic Radiopharmaceuticals (Exemplified by [153Sm]Sm-PSMA-617 and [177Lu]Lu-PSMA-617). High Energy Chem 57, 18–27 (2023). https://doi.org/10.1134/S0018143923010095

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