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Autoradiolytic Decomposition of Radiopharmaceutical 2-[18F]Fluorodeoxyglucose

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Abstract

The kinetics of autoradiolytic degradation of the radiopharmaceutical drug 2-[18F]fluorodeoxyglucose ([18F]FDG) in an air-saturated normal saline solution with initial activity concentrations of 1 and 2 GBq/mL has been studied. It has been established that the only radioactive product of radiation-induced transformations of [18F]FDG is [18F]fluoride, whose contribution in the total activity of the radiopharmaceutical increases with storage. It has been shown that an increase in the initial activity concentration of the radiopharmaceutical or a decrease in the concentration of ethanol in it leads to the enhancement of autoradiolytic degradation of [18F]FDG. However, an increase in the storage temperature of the solutions from 25 to 40°C does not affect the rate of radiation-induced dehalogenation of [18F]FDG.

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REFERENCES

  1. Ulaner, G.A., Fundamentals of Oncologic PET/CT, Amsterdam: Elsevier, 2019.

    Google Scholar 

  2. Zhuang, H. and Codreanu, I., J. Biomed. Res., 2015, vol. 29, no 3, p, 189.

  3. Brinkevich, S., Pires, L.P., Portilho, F.L., and Santos-Oliveira, R., Curr. Radiopharm., 2018, vol. 11, p. 69.

    Article  CAS  PubMed  Google Scholar 

  4. Vallabhajosula, S., Molecular Imaging: Radiopharmaceuticals for PET and SPECT, Berlin: Springer, 2009.

    Book  Google Scholar 

  5. Walters, L.R., Martin, K.J., Jacobson, M.S., Hung, J.C., and Mosman, E.A., J. Nucl. Med. Technol., 2012, vol. 40, p. 52.

    Article  PubMed  Google Scholar 

  6. Fawdry, R.M., Appl. Radiat. Isot., 2007, vol. 65, p. 1193.

    Article  CAS  PubMed  Google Scholar 

  7. Ivanyukovich, A.A., Soroka, S.A., Krot, V.O., Brinkevich, D.I., Brinkevich, S.D., Chizh, G.V., and Sverdlov, R.L., Med. Fiz., 2018, no. 4, p. 59.

  8. European Pharmacopoeia, 8th ed., Strasbourg: Council of Europe, 2013, Monograph 1325: Fludeoxyglucose (18F) injection, p. 1052.

  9. Brinkevich, S.D. and Shadyro, O.I., High Energy Chem., 2018, vol. 52, no. 4, p. 364.

    Article  CAS  Google Scholar 

  10. Buriova, E., Macasek, F., Melichar, F., Kropa, M., and Prochazka, L., J. Radioanal. Nucl. Chem., 2005, vol. 264, no. 3, p. 595.

    Article  CAS  Google Scholar 

  11. Buxton, G.V., Greenstock, C.L., Helman, W.P., and Ross, A.B., J. Phys. Chem. Ref. Data, 1988, vol. 17, no. 2, p. 513.

    Article  CAS  Google Scholar 

  12. Petryaev, E.P. and Shadyro, O.I., Radiatsionnaya khimiya bifunktsional’nykh organicheskikh soedinenii (Radiation Chemistry of Bifunctional Organic Compounds), Minsk: Universitetskoe, 1986, p. 165.

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ACKNOWLEDGMENTS

The authors are grateful to Yulia Olegovna Baskalova for assistance in studying the radiochemical purity of the radiopharmaceutical [18F]FDG.

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Authors and Affiliations

  1. Republican Scientific and Practical Center of Oncology and Medical Radiology, 223040, Lesnoi, Minsk oblast, Belarus

    S. D. Brinkevich & O. V. Tugai

  2. Blokhin National Medical Research Center of Oncology, 115478, Moscow, Russia

    D. I. Nevzorov

Authors
  1. S. D. Brinkevich
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  2. O. V. Tugai
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  3. D. I. Nevzorov
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Corresponding author

Correspondence to S. D. Brinkevich.

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Translated by S. Zatonsky

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Brinkevich, S.D., Tugai, O.V. & Nevzorov, D.I. Autoradiolytic Decomposition of Radiopharmaceutical 2-[18F]Fluorodeoxyglucose. High Energy Chem 53, 300–308 (2019). https://doi.org/10.1134/S0018143919040040

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  • DOI: https://doi.org/10.1134/S0018143919040040

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