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Effect of albumin and water-soluble analogs of vitamins E, Q, and K on the free-radical fragmentation of phospholipids

High Energy Chemistry volume 49, pages 133–137 (2015)Cite this article

Abstract

The effects of trolox C, ubiquinone Q0, phthicol, and bovine serum albumin (BSA) on the free-radical fragmentation of dimiristoyl phosphatidylglycerol (DMPG) in model membranes subjected to the action of γ-radiation have studied. It has been found that ubiquinone Q0 and phthicol more efficiently (by a factor of ∼1.8–1.9) than trolox C (by a factor of ∼1.5) decrease the radiation-chemical yield of dimiristoyl phosphatidic acid (DMPA), the molecular product of DMPG fragmentation. BSA exerts a protective effect on the fragmentation of DMPG in a dose-dependent manner; at a lipid to protein ratio of 30: 1, the yield of DMPA is decreased by a factor of 2.

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Authors and Affiliations

  1. Belarussian State University, ul. Leningradskaya 14, Minsk, 220030, Belarus

    I. V. Mel’sitova

  2. Research Institute of Physicochemical Problems, Belarussian State University, ul. Leningradskaya 14, Minsk, 220030, Belarus

    I. L. Yurkova

Authors
  1. I. V. Mel’sitova
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  2. I. L. Yurkova
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Correspondence to I. L. Yurkova.

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Original Russian Text © I.V. Mel’sitova, I.L. Yurkova, 2015, published in Khimiya Vysokikh Energii, 2015, Vol. 49, No. 3, pp. 159–163.

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Mel’sitova, I.V., Yurkova, I.L. Effect of albumin and water-soluble analogs of vitamins E, Q, and K on the free-radical fragmentation of phospholipids. High Energy Chem 49, 133–137 (2015). https://doi.org/10.1134/S001814391503011X

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  • DOI: https://doi.org/10.1134/S001814391503011X

Keywords

  • Trolox
  • Ubiquinone
  • High Energy Chemistry
  • DMPA
  • Liposomal Suspension