Abstract
The set of data presented in this work shows that the radiolysis of hydroxyl-containing amino acids in aqueous solutions results in their degradation with -C-C- bond cleavage, which leads to both the decarboxylation of parent molecules and the removal of side substituents. The probability of these reactions mainly depends on the pH of the solution. Aminyl radicals or aminium radical cations, which are formed in the interaction of serine and threonine with ·OH radicals via the mechanism of electron or hydrogen-atom transfer from the amino groups of the parent substances, play an important role in these degradation processes.
Similar content being viewed by others
References
Garrison, W.M., Chem. Rev., 1987, vol. 87, p. 31.
Von Sonntag, C., The Chemical Bases of Radiation Biology, London: Taylor and Francis, 1987.
Monig, J., Chapman, R., and Asmus, K.D., J. Phys. Chem., 1985, vol. 89, p. 3139.
Bonifacic, M., Stefanic, I., Hug, G.L., Armstrong, D.A., and Asmus, K.D., J. Am. Chem. Soc., 1998, vol. 120, p. 9930.
Sosnovskaya, A.A., Sladkova, A.A., Dobridenev, I.S., and Shadyro, O.I., High Energy Chem., 2009, vol. 43, p. 431.
Teerlink, T. and Leeuwen, P.A.M., Houdijk A, Clin. Chem., 1994, vol. 40, no. 2, p. 245.
Lin, T.G. and Morales, M.F., Anal. Biochem., 1977, vol. 77, p. 10.
Pikaev, A.K. and Kabakchi, S.A., Reaktsionnaya sposobnost’ pervichnykh produktov radioliza vody: Spravochnik (Handbook of Reactivity of Primary Water Radiolysis Products), Moscow: Energoizdat, 1982.
Petryaev, E.P. and Shadyro, O.I., Radiatsionnaya khimiya bifunktsional’nykh organicheskikh soedinenii (Radiation Chemistry of Bifunctional Organic Compounds), Minsk: Universitetskoe, 1986.
Lehninger, A.L., Nelson, D.L., and Cox, M.M., Principles of Biochemistry, New York: Worth, 2000, 3rd ed.
Hernandes, M.S. and Troncone, L.R.P., J. Neural. Transm, 2009, vol. 116, p. 1551.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A.A. Sladkova, A.A. Sosnovskaya, I.P. Edimecheva, V.A. Knizhnikov, O.I. Shadyro, 2012, published in Khimiya Vysokikh Energii, 2012, Vol. 46, No. 4, pp. 283–288.
Rights and permissions
About this article
Cite this article
Sladkova, A.A., Sosnovskaya, A.A., Edimecheva, I.P. et al. Radiation-induced degradation of hydroxyl-containing amino acids in aqueous solutions. High Energy Chem 46, 235–240 (2012). https://doi.org/10.1134/S0018143912040169
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0018143912040169