Abstract
The concept of designing analogues of natural protein enzymes based on synthetic protein-like copolymers has been described. It is assumed that target globular nanostructures with a core–shell structure should form spontaneously in a selective solvent in the course of the polymerization reaction of monomers, which can be divided into two groups (hydrophobic and hydrophilic) according to their affinity for water. The hydrophilic monomers should contain catalytically active groups. α-Chymotrypsin was used as a natural prototype of an artificial catalyst. Computer-aided simulation of the radical copolymerization reaction confirms the efficiency of the formulated concept.
Similar content being viewed by others
References
Vriezema, D.M., Aragones, M.C., Elemans, J.A.A.W., et al., Chem. Rev., 2005, vol. 105, no. 4, pp. 1445–1489.
Wulff, G., Chem. Rev., 2002, vol. 102, no. 1, pp. 1–28.
Zhang, X., Zeng, Q., and Wang, C., RSC Adv., 2013, vol. 3, no. 29, pp. 11351–11366.
Ablyazov, P.N., Vasilevskaya, V.V., and Khokhlov, A.R., Kolloid. Zh., 2007, vol. 69, no. 3, pp. 293–299.
Khokhlov, A.R. and Khalatur, P.G., Phys. Rev. Lett., 1999, vol. 82, no. 17, pp. 3456–3459.
Berezkin, A.V., Khokhlov, A.R., and Khalatur, P.G., J. Chem. Phys., 2003, vol. 118, no. 17, pp. 8049–8060.
Lozinskii, V.I., Simenel, I.A., Kurskaya, E.A., et al., Dokl. Akad. Nauk, 2000, vol. 375, no. 5, pp. 637–640.
Lozinsky, V.I., Simenel, I.A., Kulakova, V.K., et al., Macromolecules, 2003, vol. 36, no. 19, pp. 7308–7323.
Lozinskii, V.I., Simenel, I.A., and Khokhlov, A.R., Dokl. Chem., 2006, vol. 410, part 2, pp. 570–573.
Gavrilov, A.A., Komarov, P.V., and Khalatur, P.G., Macromolecules, 2015, vol. 48, no. 1, pp. 206–212.
Hoogerbrugge, P.J. and Koelman, J.M.V.A., Europhys. Lett., 1992, vol. 19, no. 3, p. 155.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © P.V. Komarov, P.G. Khalatur, A.R. Khokhlov, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 3, pp. 305–309.
Rights and permissions
About this article
Cite this article
Komarov, P.V., Khalatur, P.G. & Khokhlov, A.A.R. Principles of designing nanostructured polymeric catalysts: Mesoscopic simulation. Dokl Phys Chem 464, 222–225 (2015). https://doi.org/10.1134/S0012501615090092
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0012501615090092