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Synthesis and Antiviral Activity of Copolymers of Hydroxycinnamic Acid with N-Vinylamides

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Abstract

Radical copolymerization of coumarin with N-vinylamides (N‑vinylpyrrolidone, N-methyl-N-vinylacetamide, N-vinylformamide) has been used to prepare copolymers of various composition with variable molecular weights. Subsequent reactions in their polymer chains affords water-soluble copolymers of salts of hydroxycinnamic acid and its hydrazides. The synthesized copolymers of hydroxycinnamic acid salts and hydrazides with N-vinylamides have low cytotoxicity and demonstrate the pronounced antiviral activity against human respiratory syncytial virus (strain A2).

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Funding

The work was carried out within the framework of the State assignment of the Institute of Macromolecular Compounds of the Russian Academy of Sciences (registration no. 122012100171-8 “Nanostructuring and modification of biologically active substances with synthetic and natural polymers”), with the financial support of the Ministry of Health of the Russian Federation (topic reg. no. NIOKTR in EGISU NIOKTR 121051900142-0 “Genetic and antigenic variability of modern strains of respiratory syncytial viruses (RSV) circulating in the Russian Federation”).

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, St. Petersburg, Russia

    N. A. Nesterova &  E. F. Panarin

  2. Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 197376, St. Petersburg, Russia

    A. A. Shtro

Authors
  1. N. A. Nesterova
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  2. A. A. Shtro
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  3. E. F. Panarin
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Correspondence to N. A. Nesterova.

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This work does not contain any studies involving human and animal subjects.

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The authors declare that they have no conflicts of interest.

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Translated by G. Kirakosyan

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Nesterova, N.A., Shtro, A.A. & Panarin, E.F. Synthesis and Antiviral Activity of Copolymers of Hydroxycinnamic Acid with N-Vinylamides. Dokl Chem 513, 389–392 (2023). https://doi.org/10.1134/S0012500823600992

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  • DOI: https://doi.org/10.1134/S0012500823600992

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