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Structure and Biological Properties of 2-Phenylhydrazone Derivatives of Thiazolopyrimidines

Abstract

A number of 2-phenylhydrazone derivatives of thiazolo[3,2-a]pyrimidines has been synthesized, and their structure and biological activity have been studied. The structure of the obtained compounds has been confirmed by 1H and 13C NMR spectroscopy and X-ray diffraction analysis. It has been found that hydrazone form with Z configuration of the C=N bond is typical for the obtained derivatives. Low cytotoxicity of the synthesized compounds toward normal and tumor cell lines has been shown.

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ACKNOWLEDGMENTS

The authors thank to the Collective Spectro-Analytical Center for the Study of the Structure, Composition and Properties of Substances and Materials, Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences, for technical support of the study.

Funding

This work was financially supported by the Russian Foundation for Basic Research, project no. 20-33-90124.

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Correspondence to A. S. Agarkov.

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Translated by I. Kudryavtsev

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Agarkov, A.S., Gabitova, E.R., Galieva, F.B. et al. Structure and Biological Properties of 2-Phenylhydrazone Derivatives of Thiazolopyrimidines. Dokl Chem 503, 45–50 (2022). https://doi.org/10.1134/S0012500822030016

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  • DOI: https://doi.org/10.1134/S0012500822030016

Keywords:

  • thiazolo[3,2-a]pyrimidines
  • thiazolo[3,2-a]pyrimidine 2-phenylhydrazones
  • azo–hydrazone tautomerizm
  • E and Z isomerism
  • X-ray diffraction analysis
  • cytotoxicity
  • bioactivity