Preparation of Succinyl-Chitin Nanoparticles for Biomedical Applications

Abstract

The N-acylation of partially deacetylated chitin nanofibers with succinic anhydride gave N-succinyl-chitin. The introduction of succinyl groups into chitin nanofibers followed by sonication of the aqueous dispersion of N-succinyl-chitin gives rise to a stable aqueous dispersion (with particle hydrodynamic radius of 350 nm and ζ-potential of –22 mV). The particle morphology simultaneously changes from rod-like with (100–500) × (6–15) nm size to spherical with 160–400 nm size, whereas the chitin crystal structure barely changes.

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Correspondence to Y. A. Skorik.

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Original Russian Text © V.A. Petrova, M.M. Galagudza, Y.A. Skorik, 2018, published in Doklady Akademii Nauk, 2018, Vol. 480, No. 5, pp. 548–550.

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Petrova, V.A., Galagudza, M.M. & Skorik, Y.A. Preparation of Succinyl-Chitin Nanoparticles for Biomedical Applications. Dokl Chem 480, 114–116 (2018). https://doi.org/10.1134/S0012500818060058

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