Preparation of Succinyl-Chitin Nanoparticles for Biomedical Applications


The N-acylation of partially deacetylated chitin nanofibers with succinic anhydride gave N-succinyl-chitin. The introduction of succinyl groups into chitin nanofibers followed by sonication of the aqueous dispersion of N-succinyl-chitin gives rise to a stable aqueous dispersion (with particle hydrodynamic radius of 350 nm and ζ-potential of –22 mV). The particle morphology simultaneously changes from rod-like with (100–500) × (6–15) nm size to spherical with 160–400 nm size, whereas the chitin crystal structure barely changes.

This is a preview of subscription content, access via your institution.


  1. 1.

    Kritchenkov, A.S., Andranovits, S., and Skorik, Y.A., Russ. Chem. Rev., 2017, vol. 86, no. 3, pp. 231–239.

    Article  CAS  Google Scholar 

  2. 2.

    Berezin, A.S., Lomkova, E.A., and Skorik, Y.A., Russ. Chem. Bull., 2012, vol. 61, no. 4, pp. 781–795.

    Article  CAS  Google Scholar 

  3. 3.

    Kumar, M.N.V.R., Muzzarelli, R.A.A., Muzzarelli, C., Sashiwa, H., and Domb, A.J., Chem. Rev., 2004, vol. 104, no. 12, pp. 6017–6084.

    Article  PubMed  Google Scholar 

  4. 4.

    Dash, B.C., Rethore, G., Monaghan, M., Fitzgerald, K., Gallagher, W., and Pandit, A., Biomaterials, 2010, vol. 31, no. 32, pp. 8188–8197.

    Article  CAS  PubMed  Google Scholar 

  5. 5.

    Minami, S., Suzuki, H., Okamoto, Y., Fujinaga, T., and Shigemasa, Y., Carbohydr. Polym., 1998, vol. 36, no. 2–3, pp. 151–155.

    Article  CAS  Google Scholar 

  6. 6.

    Kato, Y., Onishi, H., and Machida, Y., Biomaterials, 2000, vol. 21, no. 15, pp. 1579–85.

    Article  CAS  PubMed  Google Scholar 

  7. 7.

    Panevin, A.A., Golyshev, A.A., Skorik, Y.A., Zhuravskii, S.G., and Sonin, D.L., Pharm. Chem. J., 2017, vol. 50, no. 11, pp. 711–714.

    Article  CAS  Google Scholar 

  8. 8.

    Skorik, Y.A., Kritchenkov, A.S., Moskalenko, Y.E., Golyshev, A.A., Raik, S.V., Whaley, A.K., Vasina, L.V., and Sonin, D.L., Carbohydr. Polym., 2017, vol. 166, pp. 166–172.

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Skorik, Y.A., Golyshev, A.A., Kritchenkov, A.S., Gasilova, E.R., Poshina, D.N., Sivaram, A.J., and Jayakumar, R., Carbohydr. Polym., 2017, vol. 162, pp. 49–55.

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    Ifuku, S., Iwasaki, M., Morimoto, M., and Saimoto, H., Carbohydr. Polym., 2012, vol. 90, no. 1, pp. 623–627.

    Article  CAS  PubMed  Google Scholar 

  11. 11.

    Golyshev, A.A., Moskalenko, Y.E., and Skorik, Y.A., Russ. Chem. Bull., 2015, vol. 64, no. 5, pp. 1168–1171.

    Article  CAS  Google Scholar 

  12. 12.

    Hirano, S. and Moriyasu, T., Carbohydr. Polym., 2004, vol. 55, no. 3, pp. 245–248.

    Article  CAS  Google Scholar 

  13. 13.

    Kiroshka, V.V., Yurchuk, T.A., Repin, N.V., Petrova, V.A., Gofman, I.V., Skorik, Y.A., Kiroshka, E.V., and Bondarenko, T.P., Bull. Exp. Biol. Med., 2014, vol. 158, no. 1, pp. 153–158.

    Article  CAS  PubMed  Google Scholar 

  14. 14.

    Lu, P. and Hsieh, Y.-L., Carbohydr. Polym., 2010, vol. 82, no. 2, pp. 329–336.

    Article  CAS  Google Scholar 

  15. 15.

    Kiroshka, V.V., Petrova, V.A., Chernyakov, D.D., Bozhkova, Y.O., Kiroshka, K.V., Baklagina, Y.G., Romanov, D.P., Kremnev, R.V., and Skorik, Y.A., J. Mater. Sci.: Mater. Med., 2017, vol. 28, no. 1, p. 21.

    Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Y. A. Skorik.

Additional information

Original Russian Text © V.A. Petrova, M.M. Galagudza, Y.A. Skorik, 2018, published in Doklady Akademii Nauk, 2018, Vol. 480, No. 5, pp. 548–550.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Petrova, V.A., Galagudza, M.M. & Skorik, Y.A. Preparation of Succinyl-Chitin Nanoparticles for Biomedical Applications. Dokl Chem 480, 114–116 (2018).

Download citation