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The Effect of Surgical Procedure in the Nasal Cavity on the Passive Avoidance Conditioning and the Hypothalamic Level of Monoamines in Rats

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Abstract

A rat biological model of septoplasty was used to study the effect of surgery on passive avoidance conditioning (PAC). Septoplasty was shown to increase anxiety and to reduce exploratory activity in rodents during PAC. A neurochemical analysis of the hypothalamus was carried out immediately after the end of the experiment and showed an increase in norepinephrine (NE) metabolism after septoplasty. The finding was tentatively associated with activation of the hypothalamic-pituitary-adrenal axis.

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Funding

This work was supported by the state assignment “Neurobiological Basis of Animal Behavior” (topic no. 11-1-21, TsITIS no. 121032500080-8).

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Authors and Affiliations

  1. Biological Faculty, Moscow State University, Moscow, Russia

    A. G. Korolev, A. N. Inozemtsev & A. V. Latanov

  2. Medical Institute, Peoples’ Friendship University of Russia, Moscow, Russia

    A. G. Korolev & I. V. Kastyro

Authors
  1. A. G. Korolev
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  2. I. V. Kastyro
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  3. A. N. Inozemtsev
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  4. A. V. Latanov
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Corresponding author

Correspondence to A. G. Korolev.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

Animal-related experiments were conducted in accordance with the Directive 2010/63/EU. Animal protocols were approved by the Ethics Committee at the Medical Institute, People’s Friendship University of Russia (protocol no. 1 dated September 18, 2020).

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The authors of this work declare that they have no conflicts of interest.

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Translated by T. Tkacheva

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Korolev, A.G., Kastyro, I.V., Inozemtsev, A.N. et al. The Effect of Surgical Procedure in the Nasal Cavity on the Passive Avoidance Conditioning and the Hypothalamic Level of Monoamines in Rats. Dokl Biol Sci (2024). https://doi.org/10.1134/S0012496624700959

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  • DOI: https://doi.org/10.1134/S0012496624700959

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