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Gender-Dependent Effect of Maternal Methyl-Enriched Diet on the Expression of Genetic Absence Epilepsy and Comorbid Depression in Adult Offspring of WAG/Rij Rats

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Abstract

In the present study it has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-methionine, zinc) during perinatal period reduces the expression of genetic absence epilepsy and comorbid depression in adult offspring of WAG/Rij rats. This beneficial effect was more pronounced in males compared with females. It is assumed that epigenetic modifications induced by maternal methyl-enriched diet in the offspring at the early stages of ontogenesis might be a possible mechanism underlying the correction of genetically-based pathologic phenotype in WAG/Rij rats. Results suggest that methyl-enriched diet during perinatal period can be potentially used for mitigation or prevention epileptogenesis and depression-like comorbid disorders in people genetically predisposed to absence epilepsy.

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Funding

The reported study was funded by RFBR, project number 20-015-00327a.

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485, Moscow, Russia

    K. Yu. Sarkisova, A. V. Gabova, E. A. Fedosova & A. B. Shatskova

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  1. K. Yu. Sarkisova
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  2. A. V. Gabova
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  3. E. A. Fedosova
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  4. A. B. Shatskova
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Correspondence to K. Yu. Sarkisova.

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Sarkisova, K.Y., Gabova, A.V., Fedosova, E.A. et al. Gender-Dependent Effect of Maternal Methyl-Enriched Diet on the Expression of Genetic Absence Epilepsy and Comorbid Depression in Adult Offspring of WAG/Rij Rats. Dokl Biol Sci 494, 244–247 (2020). https://doi.org/10.1134/S0012496620050075

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  • DOI: https://doi.org/10.1134/S0012496620050075

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