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The Effect of Ionizing Radiation on Cognitive Functions in Mouse Models of Alzheimer’s Disease

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Abstract

The present study demonstrates the effect of combined ionizing radiation (γ rays, 0.24 Gy, 661.7 keV, whole body and 12C, 0.18 Gy, 450 MeV, head region) on the behavior of animals in mouse transgenic models of Alzheimer’s disease. Significant improvement of spatial learning and stimulation of locomotor and exploratory behavior were observed in wild-type mice after irradiation. However, an anxiolytic effect and stimulation of locomotor and exploratory behavior were revealed in irradiated mice with tauopathy. Mice with cerebral amyloidosis also exhibited improved learning in the odor recognition test. No negative effects of irradiation were detected.

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Funding

This study was supported by the Russian Science Foundation (project no. 18-74-00118) and by funds under the State Contract for the Institute of Physiologically Active Compounds, Russian Academy of Sciences (no. 0090-2019-0005). This study was performed using the equipment of the Center of the Collective Use of the Institute of Physiologically Active Compounds, Russian Academy of Sciences.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    M. M. Chicheva, A. V. Mal’tsev &  S. O. Bachurin

  2. Research Center for Biomedical Technologies, Federal Biomedical Agency of Russia, 143442, Moscow, Russia

    V. S. Kokhan

Authors
  1. M. M. Chicheva
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  2. A. V. Mal’tsev
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  3. V. S. Kokhan
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  4. S. O. Bachurin
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Correspondence to M. M. Chicheva.

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Conflict of interest. The authors declare no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Stepanichev

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Chicheva, M.M., Mal’tsev, A.V., Kokhan, V.S. et al. The Effect of Ionizing Radiation on Cognitive Functions in Mouse Models of Alzheimer’s Disease. Dokl Biol Sci 494, 225–227 (2020). https://doi.org/10.1134/S0012496620050026

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  • DOI: https://doi.org/10.1134/S0012496620050026

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