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Analysis of the Healthy Subject Response to Prolonged Contact with Tuberculosis Patients

  • CELL BIOLOGY
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Abstract

Prolonged contact of healthy subjects with Mycobacterium tuberculosis can change their blood formula and immune status, thus reflecting adaptive reactions to constant antigenic load. The peripheral blood analysis of health care workers in a tuberculosis hospital demonstrates changes in cell populations which prevent development of tuberculosis, in particular, CD4+ Т cells and CD3+ Т cells. It is shown that the number of the memory CD4+ Т cells specific to M.tuberculosis antigens which produce interferon gamma depends on the duration of work contact with tuberculosis patients. The use of health care workers' blood characteristics as a control for tuberculosis patients is discussed.

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REFERENCES

  1. van Crevel, R., Ottenhoff, T.H.M., and van  der  Meer,  J.W.M., Clin. Microbiol. Rev., 2002, vol. 15, no. 2, pp. 294–315.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Muller, I., Cobbold, S.P., Waldmann, H., and Kaufmann, S.H., Infect. Imm., 1987, vol. 55, pp. 2037–2041.

    CAS  Google Scholar 

  3. Grotzke, J.E. and Lewinson, D.M., Microb. Infect., 2005, vol. 7, no. 4, pp. 776–788.

    Article  CAS  Google Scholar 

  4. Lazarevic, V. and Flynn, J., Am. J. Respir. Crit. Care Med., 2002, vol. 166, no. 8, pp. 1116–1121.

    Article  PubMed  Google Scholar 

  5. Kaufmann, S.H., Proc. Nat. Acad. Sci. U.S.A., 1996, vol. 93, pp. 2272–2277.

    Article  CAS  Google Scholar 

  6. Burnet, F.M., The Clonal Selection Theory of Acquired Immunity, Cambridge: Cambridge Univ. Press, 1959.

    Book  Google Scholar 

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    I. S. Litvinov & D. A. Dolgikh

Authors
  1. I. S. Litvinov
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  2. D. A. Dolgikh
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Correspondence to D. A. Dolgikh.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by A. Nikolaeva

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Litvinov, I.S., Dolgikh, D.A. Analysis of the Healthy Subject Response to Prolonged Contact with Tuberculosis Patients. Dokl Biol Sci 488, 153–155 (2019). https://doi.org/10.1134/S001249661905003X

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  • DOI: https://doi.org/10.1134/S001249661905003X

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