Abstract
The electrophysiological mechanism of the atrial myocardium resistance to the cold-induced arrhythmias was studied in the hibernating ground squirrel Citellus undulatus. The atrial action potentials (APs) and refractoriness were recorded with microelectrodes in isolated multicellular preparations of the atrial myocardium taken from the hibernating and summer active ground squirrels (HS and SAS, respectively) at 37, 27, and 17°С to estimate the AP and refractoriness durations. In both HS and SAS, hypothermia increased the duration of the AP and refractoriness period (APD and RD, respectively), and in both animal groups RD was longer than APD under hypothermia but not at 37°С. This last observation can be a result of the postrepolarization refractoriness (PRR), which seems to contribute substantially to the atrial myocardium tolerance of the hibernating animals to the hypothermia-induced arrhythmias because it prevents afterdepolarizations.
Similar content being viewed by others
REFERENCES
Kuz’min, V.S., Abramov, A.A., Egorov, Yu.V., and Rozenshtraukh, L.V., Ross. Fiziol. Zh. im. I.M. Sechenova, 2014, vol. 100, no. 12, pp. 1399–1408.
Fedorov, V.V., Glukhov, A.V., Sudharshan, S., Egorov, Y., Rosenshtraukh, L.V., and Efimov, I.R., Heart Rhythm, 2008, vol. 5, no. 11, pp. 1587–1596.
Yatani, A., Kim, S.J., Kudej, R.K., Wang, Q., Depre, C., Irie, K., Kranias, E.G., Vatner, S.F., and Vatner, D.E., Am. J. Physiol. Heart Circ. Physiol., 2004, vol. 286, pp. 2219–2228.
Averin, A.S., Kosarskii, L.S., Tarlachkov, S.V., Vekhnik, V.A., Averina, I.V., Alekseev, A.E., Fesenko, E.E., and Nakipova, O.V., Biofizika, 2017, vol. 62, pp. 127–133.
Zakharova, N.M., Nakipova, O.V., Averin, A.S., Ti-khonov, K.G., Solomonov, N.G., Dokl. Biol. Sci., 2009, vol. 424, no. 5, pp. 21–24.
Nakipova, O.V., Averin, A.S., Evdokimovskii, E.V., Pimenov, O.Y., Kosarski, L., Ignat’ev, D., Anufriev, A., Kokoz, Y.M., Reyes, S., Terzic, A., and Alekseev, A.E., PLoS One, 2017, vol. 12, no. 5, pp. 1–20.
Kuz'min, V.S., Abramochkin, D.V., Sukhova, G.S., and Rozenshtraukh, L.V., Kardiologiya, 2008, vol. 48, no. 11, pp. 53–60.
Marshall, J.M. and Willis, J.S., J. Physiol., 1962, vol. 164, no. 1, pp. 64–76.
Charnock, J.S., Dryden, W.F., and Marshall, R.J., Br. J. Pharmacol., 1983, vol. 78, no. 1, pp. 151–158.
Coronel, R., Janse, M.J., Opthof, T., Wilde, A.A., and Taggart, P., Heart Rhythm, 2012, vol. 9, no. 6, pp. 977–982.
Kirchhof, P., Degen, H., Franz, M.R., Eckardt, L., Fabritz, L., Milberg, P., Laer, S., Neumann, J., Breithardt, G., and Haverkamp, W., J. Pharmacol. Exp. Ther., 2003, vol. 305, no. 1, pp. 257–263.
van Hunnik, A., Lau, D.H., Zeemering, S., Kuiper, M., Verheule, S., and Schotten, U., Heart Rhythm, 2016, vol. 13, no. 4, pp. 964–972.
Frommeyer, G., Rajamani, S., Grundmann, F., Stypmann, J., Osada, N., Breithardt, G., Belardinelli, L., Eckardt, L., and Milberg, P., J. Card. Fail., 2012, vol. 18, no. 12, pp. 939–949.
Liu, B., Arlock, P., Wohlfart, B., and Johansson, B.W., Cryobiology, 1991, vol. 28, pp. 96–104.
Wang, S.Q., Lakatta, E.G., Cheng, H., and Zhou, Z.Q., J. Exp. Biol., 2002, vol. 205, pp. 2957–2962.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by A. Nikolaeva
Rights and permissions
About this article
Cite this article
Kuzmin, V.S., Abramov, A.A., Egorov, Y.V. et al. Hypothermia-Induced Postrepolarization Refractoriness Is the Reason of the Atrial Myocardium Tolerance to the Bioelectrical Activity Disorders in the Hibernating and Active Ground Squirrel Citellus undulatus. Dokl Biol Sci 486, 63–68 (2019). https://doi.org/10.1134/S0012496619030050
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0012496619030050