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α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations

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Abstract

The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.

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References

  1. Terentiev, A.A. and Moldogazieva, N.T., Tumor Biol., 2013, vol. 34, pp. 2075–2091.

    Article  CAS  Google Scholar 

  2. Schumacher, A., Costa, S.D., and Zenclussen, A.C., Endocrine factors modulating immune responses in pregnancy, Front. Immunol., 2014.

    Google Scholar 

  3. Chereshnev, V.A., Timganova, V.P., Zamorina, S.A., Bochkova, M.S., Khramtsov, P.V., Kropaneva, M.D., and Raev, M.B., Dokl. Biol. Sci., 2017, vol. 477, pp. 248–251.

    Article  PubMed  CAS  Google Scholar 

  4. Sallusto, F., Geginat, J., and Lanzavecchia, A., Central memory and effector memory t cell subsets: function, generation, and maintenance, Annu. Rev. Immunol, 2004, vol. 22, pp. 745–763.

    Article  PubMed  CAS  Google Scholar 

  5. Kudryavtsev, I.V., Ross. Immunol. Zh., 2014, vol. 8, no. 4, pp. 947–964.

    Google Scholar 

  6. Henson, S.M., Riddell, N.E., and Akbar, A.N., Curr. Opin. Immunol., 2012, vol. 24, no. 4, pp. 476–481.

    Article  PubMed  CAS  Google Scholar 

  7. Litvinova, L.S., Gutsol A.A., Sokhonevich, N.A., Kofanova, K.A., Khaziakhmatova, O.G., Shupletsova, V.V., Kaigorodova, E.V., and Goncharov, A.G., Med. Immunol., 2014, vol. 16, no. 1, pp. 7–26.

    Article  Google Scholar 

  8. Kieffer, T.E., Faas, M.M., Scherjon, S.A., and Prins, J.R., Pregnancy persistently affects memory T cell populations, J. Reprod. Immunol., 2016, vol. 119, pp. 1–8.

    Article  PubMed  CAS  Google Scholar 

  9. Gagnon, A., Wilson, R.D., Audibert, F., Allen, V.M., Blight, C., Brock, J.A., Desilets, V.A., Johnson, J.A., Langlois, S., Summers, A., and Wyatt, P., J. Obstetr. Gynaecol. Can., 2008, vol. 30, pp. 918–932.

    Article  Google Scholar 

  10. Geginat, J., Sallusto, F., and Lanzavecchia, A., J. Exp. Med., 2001, vol. 194, no. 12, pp. 1711–1719.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Saunders, A.E., Shim, Y.A., and Johnson, P., J. Immunol., 2014, vol. 193, no. 6, pp. 2831–2842.

    Article  PubMed  CAS  Google Scholar 

  12. Mizejewski, G.J., J. Drug Target, 2015, vol. 23, no. 6, pp. 538–551.

    Article  PubMed  CAS  Google Scholar 

  13. Farber, D.L., Yudanin, N.A., and Restifo, N.P., Nat. Rev. Immunol., 2014, vol. 14, no. 1, pp. 24–35.

    Article  PubMed  CAS  Google Scholar 

  14. Kudryashova, A.V., Sotnikova, N.Yu., Panov, I.A., and Kadyrova, L.V., Zh. Akush. Zhensk. Bol., 2013, vol. 62, no. 2, pp. 110–115.

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia

    S. A. Zamorina, V. P. Timganova, M. S. Bochkova, P. V. Khramtsov, M. B. Rayev & V. A. Chereshnev

  2. Perm State National Research University, Perm, Russia

    S. A. Zamorina, P. V. Khramtsov, K. A. Fomicheva, M. B. Rayev & V. A. Chereshnev

  3. Ural Federal University, Yekaterinburg, Russia

    M. B. Rayev & V. A. Chereshnev

Authors
  1. S. A. Zamorina
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  2. V. P. Timganova
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  3. M. S. Bochkova
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  4. P. V. Khramtsov
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  5. K. A. Fomicheva
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  6. M. B. Rayev
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  7. V. A. Chereshnev
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Corresponding author

Correspondence to V. P. Timganova.

Additional information

Original Russian Text © S.A. Zamorina, V.P. Timganova, M.S. Bochkova, P.V. Khramtsov, K.A. Fomicheva, M.B. Rayev, V.A. Chereshnev, 2018, published in Doklady Akademii Nauk, 2018, Vol. 482, No. 4.

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Zamorina, S.A., Timganova, V.P., Bochkova, M.S. et al. α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations. Dokl Biol Sci 482, 210–213 (2018). https://doi.org/10.1134/S0012496618050113

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  • DOI: https://doi.org/10.1134/S0012496618050113

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