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Role of α-fetoprotein in differentiation of regulatory T lymphocytes

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Abstract

The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells. In the study of Treg differentiation, it was found that AFP at concentrations of 50 and 100 μg/mL significantly inhibited the number of nonproliferating CD4+FOXP3+ and CD4+FOXP3+HELIOS+ lymphocytes without affecting the expression of Treg markers by proliferating CD4+ lymphocytes.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia

    V. A. Chereshnev, V. P. Timganova, S. A. Zamorina, M. S. Bochkova, P. V. Khramtsov & M. B. Raev

  2. Perm State National Research University, Perm, Russia

    V. A. Chereshnev, S. A. Zamorina, P. V. Khramtsov, M. D. Kropaneva & M. B. Raev

  3. Ural Federal University, Yekaterinburg, Russia

    V. A. Chereshnev & M. B. Raev

Authors
  1. V. A. Chereshnev
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  2. V. P. Timganova
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  3. S. A. Zamorina
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  4. M. S. Bochkova
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  5. P. V. Khramtsov
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  6. M. D. Kropaneva
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  7. M. B. Raev
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Corresponding author

Correspondence to V. P. Timganova.

Additional information

Original Russian Text © V.A. Chereshnev, V.P. Timganova, S.A. Zamorina, M.S. Bochkova, P.V. Khramtsov, M.D. Kropaneva, M.B. Raev, 2017, published in Doklady Akademii Nauk, 2017, Vol. 477, No. 4, pp. 496–499.

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Chereshnev, V.A., Timganova, V.P., Zamorina, S.A. et al. Role of α-fetoprotein in differentiation of regulatory T lymphocytes. Dokl Biol Sci 477, 248–251 (2017). https://doi.org/10.1134/S0012496617060084

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  • DOI: https://doi.org/10.1134/S0012496617060084

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