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β-Adrenergic stimulation induces pro-arrhythmic activity in the caval vein myocardial tissue

Doklady Biological Sciences volume 476, pages 183–187 (2017)Cite this article

Abstract

Electrical activity of the right superior vena cava (SVC) is considered as a source of the atrial fibrillation. We have shown that bioelectrical properties of the SVC myocardium differ from those of the working atrial myocardium. Electrically evoked action potential duration in SVC is significantly shorter, the resting membrane potential in both stimulated and quiescent SVC preparations is significantly more positive than in atria. Activation of β-adrenoreceptors in SVC myocardium leads to a series of action potentials, and this process depends on protein kinase A. Probably, β-adrenergic stimulation enhances SVC arrhythmogenesis in vivo.

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Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, Moscow State University, Moscow, Russia

    A. D. Ivanova & V. S. Kuzmin

  2. Pirogov National Research Medical University, Ministry of Health, Moscow, Russia

    V. S. Kuzmin

  3. Institute of Experimental Cardiology, Russian Cardiology Research Center, Ministry of Health, Moscow, Russia

    L. V. Rosenshtraukh

Authors
  1. A. D. Ivanova
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  2. V. S. Kuzmin
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  3. L. V. Rosenshtraukh
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Correspondence to A. D. Ivanova.

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Ivanova, A.D., Kuzmin, V.S. & Rosenshtraukh, L.V. β-Adrenergic stimulation induces pro-arrhythmic activity in the caval vein myocardial tissue. Dokl Biol Sci 476, 183–187 (2017). https://doi.org/10.1134/S0012496617050027

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  • DOI: https://doi.org/10.1134/S0012496617050027